Off-target effects of cytidine base editor and adenine base editor: What can we do?

被引:2
|
作者
Liang, Puping [1 ,2 ,3 ,4 ]
Wen, Jinkun [1 ,2 ,3 ,4 ,5 ]
Huang, Junjiu [1 ,2 ,3 ,4 ,6 ]
机构
[1] Sun Yat Sen Univ, Sch Life Sci, Key Lab Reprod Med Guangdong Prov, Guangzhou 510275, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510275, Peoples R China
[3] Sun Yat Sen Univ, Sch Life Sci, SYSU BCM Joint Res Ctr, MOE Key Lab Gene Funct & Regulat, Guangzhou 510275, Peoples R China
[4] Sun Yat Sen Univ, Sch Life Sci, SYSU BCM Joint Res Ctr, Guangzhou Key Lab Hlth Aging Res, Guangzhou 510275, Peoples R China
[5] Sun Yat Sen Univ, Jiangmen Cent Hosp, Affiliated Jiangmen Hosp, Guangzhou 510150, Peoples R China
[6] Guangzhou Med Univ, Affiliated Hosp 3, Key Lab Reprod Med Guangdong Prov, Guangzhou 510150, Peoples R China
基金
国家重点研发计划;
关键词
GENOMIC DNA; RNA; DEAMINASE;
D O I
10.1016/j.jgg.2019.09.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:509 / 512
页数:4
相关论文
共 50 条
  • [1] Off-target effects of cytidine base editor and adenine base editor:What can we do?
    Puping Liang
    Jinkun Wen
    Junjiu Huang
    JournalofGeneticsandGenomics, 2019, 46 (11) : 509 - 512
  • [2] Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity
    Neugebauer, Monica E.
    Hsu, Alvin
    Arbab, Mandana
    Krasnow, Nicholas A.
    McElroy, Amber N.
    Pandey, Smriti
    Doman, Jordan L.
    Huang, Tony P.
    Raguram, Aditya
    Banskota, Samagya
    Newby, Gregory A.
    Tolar, Jakub
    Osborn, Mark J.
    Liu, David R.
    NATURE BIOTECHNOLOGY, 2023, 41 (05) : 673 - +
  • [3] Off-target effects of base editors: what we know and how we can reduce it
    Slesarenko, Yana S.
    Lavrov, Alexander V.
    Smirnikhina, Svetlana A.
    CURRENT GENETICS, 2022, 68 (01) : 39 - 48
  • [4] Engineering of near-PAMless adenine base editor with enhanced editing activity and reduced off-target
    Cao, Xiaofang
    Guo, Junfan
    Huang, Shisheng
    Yu, Wenxia
    Li, Guanglei
    An, Lisha
    Li, Xiangyang
    Tao, Wanyu
    Liu, Qing
    Huang, Xingxu
    Jin, Xiaohua
    Ma, Xu
    MOLECULAR THERAPY NUCLEIC ACIDS, 2022, 28 : 732 - 742
  • [5] A precise and efficient adenine base editor
    Tu, Tianxiang
    Song, Zongming
    Liu, Xiaoyu
    Wang, Shengxing
    He, Xiaoxue
    Xi, Haitao
    Wang, Jiahua
    Yan, Tong
    Chen, Haoran
    Zhang, Zhenwu
    Lv, Xiujuan
    Lv, Jineng
    Huang, Xiu-Feng
    Zhao, Junzhao
    Lin, Chao-Po
    Gao, Caixia
    Zhang, Jinwei
    Gu, Feng
    MOLECULAR THERAPY, 2022, 30 (09) : 2933 - 2941
  • [6] Eliminating predictable DNA off-target effects of cytosine base editor by using dual guiders including sgRNA and TALE
    Zhou, Jizeng
    Liu, Yang
    Wei, Yuhui
    Zheng, Shuwen
    Gou, Shixue
    Chen, Tao
    Yang, Yang
    Lan, Ting
    Chen, Min
    Liao, Yuan
    Zhang, Quanjun
    Tang, Chengcheng
    Liu, Yu
    Wu, Yunqin
    Peng, Xiaohua
    Gao, Minghui
    Wang, Junwei
    Zhang, Kun
    Lai, Liangxue
    Zou, Qingjian
    MOLECULAR THERAPY, 2022, 30 (07) : 2443 - 2451
  • [7] Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
    Zuo, Erwei
    Sun, Yidi
    Wei, Wu
    Yuan, Tanglong
    Ying, Wenqin
    Sun, Hao
    Yuan, Liyun
    Steinmetz, Lars M.
    Li, Yixue
    Yang, Hui
    SCIENCE, 2019, 364 (6437) : 289 - +
  • [8] Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations
    Wang, Lijie
    Xue, Wei
    Zhang, Hongxia
    Gao, Runze
    Qiu, Houyuan
    Wei, Jia
    Zhou, Lina
    Lei, Yun-Ni
    Wu, Xiaocheng
    Li, Xiao
    Liu, Chengfang
    Wu, Jing
    Chen, Qiubing
    Ma, Hanhui
    Huang, Xingxu
    Cai, Cheguo
    Zhang, Ying
    Yang, Bei
    Yin, Hao
    Yang, Li
    Chen, Jia
    NATURE CELL BIOLOGY, 2021, 23 (05) : 552 - +
  • [9] Evolved cytidine and adenine base editors with high precision and minimized off-target activity by a continuous directed evolution system in mammalian cells
    Zhao, Na
    Zhou, Jian
    Tao, Tianfu
    Wang, Qi
    Tang, Jie
    Li, Dengluan
    Gou, Shixue
    Guan, Zhihong
    Olajide, Joshua Seun
    Lin, Jiejing
    Wang, Shuo
    Li, Xiaoping
    Zhou, Jiankui
    Gao, Zongliang
    Wang, Gang
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [10] In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA
    Villiger, Lukas
    Rothgangl, Tanja
    Witzigmann, Dominik
    Oka, Rurika
    Lin, Paulo J. C.
    Qi, Weihong
    Janjuha, Sharan
    Berk, Christian
    Ringnalda, Femke
    Beattie, Mitchell B.
    Stoffel, Markus
    Thony, Beat
    Hall, Jonathan
    Rehrauer, Hubert
    van Boxtel, Ruben
    Tam, Ying K.
    Schwank, Gerald
    NATURE BIOMEDICAL ENGINEERING, 2021, 5 (02) : 179 - 189