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Protective immunity induced by live attenuated simian immunodeficiency virus
被引:115
作者:
Johnson, RP
Desrosiers, RC
机构:
[1] Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Immunol, Southborough, MA 01772 USA
[2] Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Div Microbiol, Southborough, MA 01772 USA
[3] Massachusetts Gen Hosp, Infect Dis Unit, Boston, MA 02115 USA
[4] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02115 USA
关键词:
D O I:
10.1016/S0952-7915(98)80118-0
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and continued study promises a better understanding of the nature of protective immune responses. Recent evidence supports involvement of both cytotoxic T lymphocytes and neutralizing antibodies in protective immunity against infection by simian immunodeficiency virus, but more detailed studies are needed to document their relative importance.
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页码:436 / 443
页数:8
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