Comparative evaluation of the therapeutic effect of metformin monotherapy with metformin and acupuncture combined therapy on weight loss and insulin sensitivity in diabetic patients

被引:74
作者
Firouzjaei, A. [1 ]
Li, G-C [2 ]
Wang, N. [1 ]
Liu, W-X [1 ]
Zhu, B-M [1 ]
机构
[1] Nanjing Univ Chinese Med, Clin Sch 2, Key Lab Acupuncture & Med Res, Minister Educ, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Chinese Med, Dept Epidemiol & Biostat, Nanjing 210023, Jiangsu, Peoples R China
来源
NUTRITION & DIABETES | 2016年 / 6卷
基金
中国国家自然科学基金;
关键词
LINKING OBESITY; BETA-ENDORPHIN; RESISTANCE; ELECTROACUPUNCTURE; MECHANISMS; GLUCOSE;
D O I
10.1038/nutd.2016.16
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: Obesity induces insulin resistance (IR), the key etiologic defect of type 2 diabetes mellitus (T2DM). Therefore, an incidence of obesity-induced diabetes is expected to decrease if obesity is controlled. Although Metformin is currently one of the main treatment options for T2DM in obese patients, resulting in an average of 5% weight loss, adequate weight control in all patients cannot be achieved with Metformin alone. Thus, additional therapies with a weight loss effect, such as acupuncture, may improve the effectiveness of Metformin. SUBJECTIVE: We designed this randomized clinical trial (RCT) to compare the effects of Metformin monotherapy with that of Metformin and acupuncture combined therapy on weight loss and insulin sensitivity among overweight/obese T2DM patients, to understand whether acupuncture plus Metformin is a better approach than Metformin only on treating diabetes. To understand whether acupuncture can be an insulin sensitizer and, if so, its therapeutic mechanism. RESULTS: Our results show that Metformin and acupuncture combined therapy significantly improves body weight, body mass index (BMI), fasting blood sugar (FBS), fasting insulin (FINS), homeostasis model assessment (HOMA) index, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), leptin, adiponectin, glucagon-like peptide-1 (GLP-1), resistin, serotonin, free fatty acids (FFAs), triglyceride (TG), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc) and ceramides. CONCLUSIONS: Consequently, Metformin and acupuncture combined therapy is more effective than Metformin only, proving that acupuncture is an insulin sensitizer and is able to improve insulin sensitivity possibly by reducing body weight and inflammation, while improving lipid metabolism and adipokines. As a result, electro-acupuncture (EA) might be useful in controlling the ongoing epidemics in obesity and T2DM.
引用
收藏
页码:e209 / e209
页数:9
相关论文
共 48 条
[1]   The Effects of Body Acupuncture on Obesity: Anthropometric Parameters, Lipid Profile, and Inflammatory and Immunologic Markers [J].
Abdi, Hamid ;
Zhao, Baixiao ;
Darbandi, Mahsa ;
Ghayour-Mobarhan, Majid ;
Tavallaie, Shima ;
Rahsepar, Amir Ali ;
Parizadeh, Seyyed Mohammad Reza ;
Safariyan, Mohammad ;
Nemati, Mohsen ;
Mohammadi, Maryam ;
Abbasi-Parizad, Parisa ;
Darbandi, Sara ;
Akhlaghi, Saeed ;
Ferns, Gordon A. A. .
SCIENTIFIC WORLD JOURNAL, 2012,
[2]  
ALLISON DB, 1995, INT J OBESITY, V19, P653
[3]  
Almeida-Pititto B De, DIABETES METAB SYNDR, V8, P17
[4]  
Bastard JP, 2006, EUR CYTOKINE NETW, V17, P4
[5]   Acupuncture in the treatment of obesity: a narrative review of the literature [J].
Belivani, Maria ;
Dimitroula, Charikleia ;
Katsiki, Niki ;
Apostolopoulou, Martha ;
Cummings, Mike ;
Hatzitollos, Apostolos I. .
ACUPUNCTURE IN MEDICINE, 2013, 31 (01) :88-97
[6]   Electroacupuncture therapy for weight loss reduces serum total cholesterol, triglycerides, and LDL cholesterol levels in obese women [J].
Cabioglu, MT ;
Ergene, N .
AMERICAN JOURNAL OF CHINESE MEDICINE, 2005, 33 (04) :525-533
[7]   Molecular therapy of obesity and diabetes by a physiological autoregulatory approach [J].
Cao, Lei ;
Lin, En-Ju D. ;
Cahill, Michael C. ;
Wang, Chuansong ;
Liu, Xianglan ;
During, Matthew J. .
NATURE MEDICINE, 2009, 15 (04) :447-454
[8]   Enhanced insulin sensitivity using electroacupuncture on bilateral Zusanli acupoints (ST 36) in rats [J].
Chang, Shih-Liang ;
Lin, Kuo-Juei ;
Lin, Rong-Tsung ;
Hung, Pei-Hsiu ;
Lin, Jaung-Geng ;
Cheng, Juei-Tang .
LIFE SCIENCES, 2006, 79 (10) :967-971
[9]   Involvement of serotonin in the hypoglycemic response to 2Hz electroacupuncture of zusanli acupoint (ST36) in rats [J].
Chang, SL ;
Tsai, CC ;
Lin, JG ;
Hsieh, CL ;
Lin, RT ;
Cheng, JT .
NEUROSCIENCE LETTERS, 2005, 379 (01) :69-73
[10]   The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study [J].
Charles, MA ;
Eschwege, E ;
Thibult, N ;
Claude, JR ;
Warnet, JM ;
Rosselin, GE ;
Girard, J ;
Balkau, B .
DIABETOLOGIA, 1997, 40 (09) :1101-1106