Attenuation of allergic airway inflammation and hyperresponsiveness in a murine model of asthma by silver nanoparticles

被引：0

作者：

Park, Hee Sun ^{[1
]}

Kim, Keun Hwa ^{[1
]}

Jang, Sunhyae ^{[1
]}

Park, Ji Won ^{[1
]}

Cha, Hye Rim ^{[1
]}

Lee, Jeong Eun ^{[1
]}

Kim, Ju Ock ^{[1
]}

Kim, Sun Young ^{[1
]}

Lee, Choong Sik ^{[2
]}

Kim, Joo Pyung

Jung, Sung Soo ^{[1
]}

机构：

[1] Chungnam Natl Univ, Sch Med, Dept Internal Med, Div Pulmonol Allergy & Crit Care Med, Taejon, South Korea

[2] Chungnam Natl Univ, Sch Med, Dept Pathol, Taejon, South Korea

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2010年 / 5卷

关键词：

allergic airway disease; NF-kappa B; oxidative stress; silver nanoparticles; NF-KAPPA-B; NANOCRYSTALLINE SILVER; TRANSCRIPTION FACTOR; OXIDATIVE STRESS; PLATINUM NANOPARTICLE; CONTACT-DERMATITIS; SUPEROXIDE ANION; IN-VITRO; T-CELLS; ACTIVATION;

D O I：

暂无

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The use of silver in the past demonstrated the certain antimicrobial activity, though this has been replaced by other treatments. However, nanotechnology has provided a way of producing pure silver nanoparticles, and it shows cytoprotective activities and possible pro-healing properties. But, the mechanism of silver nanoparticles remains unknown. This study was aimed to investigate the effects of silver nanoparticles on bronchial inflammation and hyperresponsiveness. We used ovalbumin (OVA)-inhaled female C57BL/6 mice to evaluate the roles of silver nanoparticles and the related molecular mechanisms in allergic airway disease. In this study with an OVA-induced murine model of allergic airway disease, we found that the increased inflammatory cells, airway hyperresponsiveness, increased levels of IL-4, IL-5, and IL-13, and the increased NF-kappa B levels in lungs after OVA inhalation were significantly reduced by the administration of silver nanoparticles. In addition, we have also found that the increased intracellular reactive oxygen species (ROS) levels in bronchoalveolar lavage fluid after OVA inhalation were decreased by the administration of silver nanoparticles. These results indicate that silver nanoparticles may attenuate antigen-induced airway inflammation and hyperresponsiveness. And antioxidant effect of silver nanoparticles could be one of the molecular bases in the murine model of asthma. These findings may provide a potential molecular mechanism of silver nanoparticles in preventing or treating asthma.

引用

页码：505 / 515

页数：11

共 67 条

[31] Ruthenium nanoparticles supported on hydroxyapatite as an efficient and recyclable catalyst for cis-dihydroxylation and oxidative cleavage of alkenes [J].