Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat

被引:36
作者
Li, Hong-Bao [1 ]
Xu, Meng-Lu [2 ]
Du, Meng-Meng [1 ]
Yu, Xiao-Jing [1 ]
Bai, Juan [3 ]
Xia, Wen-Jie [1 ]
Dai, Zhi-Ming [4 ]
Li, Chang-Xing [5 ]
Li, Ying [1 ]
Su, Qing [1 ]
Wang, Xiao-Min [1 ]
Dong, Yuan-Yuan [1 ]
Kang, Yu-Ming [1 ]
机构
[1] Xi An Jiao Tong Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Xian 710061, Peoples R China
[2] Xian Med Univ, Dept Nephrol, Affiliated Hosp 1, Xian 710077, Peoples R China
[3] Xi An Jiao Tong Univ, Affiliated Hosp 1, Ctr Brian Sci, Dept Anesthesiol, Xian 710061, Peoples R China
[4] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Anesthesia, Xian 710004, Peoples R China
[5] Qinghai Univ, Dept Human Anat, Med Coll, Xining 810000, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Curcumin; Hypertension; Gut microbiota; Butyrate; Gut-brain axis; PARAVENTRICULAR NUCLEUS; OXIDATIVE STRESS; CYTOKINES; SYSTEM;
D O I
10.1016/j.taap.2021.115701
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Gut dysbiosis and dysregulation of gut-brain communication have been identified in hypertensive patients and animal models. Previous studies have shown that probiotic or prebiotic treatments exert positive effects on the pathophysiology of hypertension. This study aimed to examine the hypothesis that the microbiota-gut-brain axis is involved in the antihypertensive effects of curcumin, a potential prebiotic obtained from Curcuma longa. Male 8- to 10-week-old spontaneously hypertensive rats (SHRs) and Wistar Kyoto (WKY) rats were divided into four groups: WKY rats and SHRs treated with vehicle and SHRs treated with curcumin in dosage of 100 or 300 mg/kg/ day for 12 weeks. Our results show that the elevated blood pressure of SHRs was markedly decreased in both curcumin-treated groups. Curcumin treatment also altered the gut microbial composition and improved intestinal pathology and integrity. These factors were associated with reduced neuroinflammation and oxidative stress in the hypothalamus paraventricular nucleus (PVN). Moreover, curcumin treatment increased butyrate levels in the plasma, which may be the result of increased butyrate-producing gut microorganisms. In addition, curcumin treatment also activated G protein-coupled receptor 43 (GPR 43) in the PVN. These results indicate that curcumin reshapes the composition of the gut microbiota and ameliorates the dysregulation of the gut-brain communication to induce antihypertensive effects.
引用
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页数:12
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