Macrophage Cell Membrane-Cloaked Nanoplatforms for Biomedical Applications

被引：142

作者：

Lopes, Joana ^{[1
]}

Lopes, Daniela ^{[1
]}

Pereira-Silva, Miguel ^{[1
,2
]}

Peixoto, Diana ^{[1
,2
]}

Veiga, Francisco ^{[1
,2
]}

Hamblin, Michael R. ^{[3
,4
,5
]}

Conde, Joao ^{[6
,7
]}

Corbo, Claudia ^{[8
,9
]}

Zare, Ehsan Nazarzadeh ^{[10
]}

Ashrafizadeh, Milad ^{[11
]}

Tay, Franklin R. ^{[12
]}

Chen, Chengshui ^{[13
]}

Donnelly, Ryan F.

Wang, Xiangdong ^{[14
]}

Makvandi, Pooyan ^{[15
]}

Paiva-Santos, Ana Claudia ^{[1
,2
]}

机构：

[1] Univ Coimbra, Fac Pharm, Dept Pharmaceut Technol, P-3000548 Coimbra, Portugal

[2] Univ Coimbra, Fac Pharm, Grp Pharmaceut Technol, REQUIMTE LAQV, P-3000548 Coimbra, Portugal

[3] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[4] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA

[5] Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[6] Univ Nova Lisboa, Fac Ciencias Med, NOVA Med Sch, P-1169056 Lisbon, Portugal

[7] Univ Nova Lisboa, Fac Ciencias Med, NOVA Med Sch, Ctr Toxicogen & Human Hlth Genet Oncol & Human To, P-1169056 Lisbon, Portugal

[8] Univ Milano Bicocca, Nanomed Ctr Nanomib, Sch Med & Surg, I-20854 Vedano Al Lambro, Italy

[9] IRCCS Ist Ortoped Galeazzi, Milan, Italy

[10] Damghan Univ, Sch Chem, Damghan 3671641167, Iran

[11] Sabanci Univ, Fac Engn & Nat Sci, TR-34956 Istanbul, Turkey

[12] Augusta Univ, Grad Sch, Augusta, GA 30912 USA

[13] Wenzhou Med Univ, Quzhou Hosp, Dept Resp Med, Quzhou 324000, Zhejiang, Peoples R China

[14] Fudan Univ, Shanghai Med Coll, Zhongshan Hosp, Dept Pulm & Crit Care Med, Shanghai 200032, Peoples R China

[15] Ist Italiano Tecnol, Ctr Mat Interface, I-56025 Pisa, Italy

来源：

SMALL METHODS | 2022年 / 6卷 / 08期

关键词：

biointerfaces; biomimetic nanoparticles; cancer; cell membrane-coated nanosystems; inflammation; macrophages; CAMOUFLAGED NANOPARTICLES; COATED NANOPARTICLES; BIOMIMETIC PLATFORM; ANTI-INFLAMMATION; DRUG-DELIVERY; TUMOR; NANOCARRIERS; IMMUNOTHERAPY; THERAPY; NANOTHERAPEUTICS;

D O I：

10.1002/smtd.202200289

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Biomimetic approaches utilize natural cell membrane-derived nanovesicles to camouflage nanoparticles to circumvent some limitations of nanoscale materials. This emergent cell membrane-coating technology is inspired by naturally occurring intercellular interactions, to efficiently guide nanostructures to the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, the intrinsic biocompatibility of cell membranes allows the crossing of biological barriers and avoids elimination by the immune system. This results in enhanced blood circulation time and lower toxicity in vivo. Macrophages are the major phagocytic cells of the innate immune system. They are equipped with a complex repertoire of surface receptors, enabling them to respond to biological signals, and to exhibit a natural tropism to inflammatory sites and tumorous tissues. Macrophage cell membrane-functionalized nanosystems are designed to combine the advantages of both macrophages and nanomaterials, improving the ability of those nanosystems to reach target sites. Recent studies have demonstrated the potential of these biomimetic nanosystems for targeted delivery of drugs and imaging agents to tumors, inflammatory, and infected sites. The present review covers the preparation and biomedical applications of macrophage cell membrane-coated nanosystems. Challenges and future perspectives in the development of these membrane-coated nanosystems are addressed.

引用

页数：42

共 160 条

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