Cerebral amyloid angiopathy related hemorrhage after stroke thrombolysis: Case report and literature review

被引：13
作者：
Mattila, Olli S. [1 ,4 ,5 ]
Sairanen, Tiina [1 ]
Laakso, Elina [1 ]
Paetau, Anders [2 ]
Tanskanen, Maarit [3 ]
Lindsberg, Perttu J. [1 ,4 ,5 ]
机构：
[1] Helsinki Univ Cent Hosp, Dept Neurol, Helsinki, Finland
[2] Helsinki Univ Cent Hosp, Dept Pathol, Helsinki, Finland
[3] Kanta Hame Cent Hosp, Dept Pathol, Hameenlinna, Finland
[4] Univ Helsinki, Res Program Mol Neurol, Res Programs Unit, Helsinki, Finland
[5] Univ Helsinki, Dept Clin Neurosci, Helsinki, Finland
来源：
NEUROPATHOLOGY | 2015年 / 35卷 / 01期
关键词：
cerebral amyloid angiopathy; intracerebral hemorrhage; ischemic stroke; subarachnoid hemorrhage; thrombolysis; ACUTE ISCHEMIC-STROKE; INTRACEREBRAL HEMORRHAGE; INTRACRANIAL HEMORRHAGE; SAFE IMPLEMENTATION; THERAPY; RISK; PA;
D O I：
10.1111/neup.12152
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cerebral amyloid angiopathy (CAA) predisposes to symptomatic intracerebral hemorrhage (sICH) after combined thrombolytic and anticoagulant treatment of acute myocardial infarction. However, the role of CAA in stroke thrombolysis has not been established. Here, we describe a confirmed case of CAA-related hemorrhage in a patient receiving thrombolysis for acute ischemic stroke. On autopsy, immunohistochemistry revealed amyloid- positive staining in thickened cortical and meningeal arteries at sites of hemorrhage. Further research is urgently needed to determine the hemorrhage risk related to CAA in stroke thrombolysis and develop better diagnostic tools to identify CAA in the emergency room.
引用
收藏
页码：70 / 74
页数：5
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