Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder: a voxel-based morphometry study

被引：41

作者：

Cai, Yi ^{[1
,3
,4
]}

Liu, Jun ^{[2
]}

Zhang, Li ^{[1
]}

Liao, Mei ^{[1
]}

Zhang, Yan ^{[1
]}

Wang, Lifeng ^{[1
]}

Peng, Hongjun ^{[1
,5
]}

He, Zhong ^{[2
]}

Li, Zexuan ^{[1
]}

Li, Weihui ^{[1
]}

Lu, Shaojia ^{[1
]}

Ding, Yuqiang ^{[1
,6
]}

Li, Lingjiang ^{[1
,7
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Natl Technol Inst Psychiat, Mental Hlth Inst,Key Lab Psychiat & Mental Hlth H, Changsha 410011, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp 2, Dept Radiol, Changsha 410011, Hunan, Peoples R China

[3] Brain Hosp Hunan Prov, Dept Mental Hlth & Psychiat, Changsha 410007, Hunan, Peoples R China

[4] Hunan Univ, Chinese Med Clin Med Coll, Changsha 410007, Hunan, Peoples R China

[5] Guangzhou Psychiat Hosp, Affiliated Hosp, Guangzhou Med Coll, Guangzhou 510370, Guangdong, Peoples R China

[6] Tongji Univ, East Hosp, Sch Med, Key Lab Arrhythmias,Minist Educ, Shanghai 200092, Peoples R China

[7] Shenzhen Kangning Hosp Guangdong Prov, Shenzhen 518003, Peoples R China

来源：

NEUROSCIENCE BULLETIN | 2015年 / 31卷 / 01期

基金：

中国国家自然科学基金;

关键词：

bipolar depressive disorder; unipolar depressive disorder; prefrontal cortex; cingulate gyrus; voxel-based morphometry; ANTERIOR CINGULATE CORTEX; GRAY-MATTER; FUNCTIONAL NEUROANATOMY; COGNITIVE IMPAIRMENT; EMOTION PERCEPTION; STRUCTURAL-CHANGES; RATING-SCALE; METAANALYSIS; DENSITY; SCHIZOPHRENIA;

D O I：

10.1007/s12264-014-1485-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bipolar disorder and unipolar depressive disorder (UD) may be different in brain structure. In the present study, we performed voxel-based morphometry (VBM) to quantify the grey matter volumes in 23 patients with bipolar I depressive disorder (BP1) and 23 patients with UD, and 23 age-, gender-, and education-matched healthy controls (HCs) using magnetic resonance imaging. We found that compared with the HC and UD groups, the BP1 group showed reduced grey matter volumes in the right inferior frontal gyrus and middle cingulate gyrus, while the UD group showed reduced volume in the right inferior frontal gyrus compared to HCs. In addition, correlation analyses revealed that the grey matter volumes of these regions were negatively correlated with the Hamilton depression rating scores. Taken together, the results of our study suggest that decreased grey matter volume of the right inferior frontal gyrus is a common abnormality in BP1 and UD, and decreased grey matter volume in the right middle cingulate gyrus may be specific to BP1.

引用

页码：4 / 12

页数：9

共 58 条

[1] Voxel-based study of structural changes in first-episode patients with bipolar disorder [J].