Robust response to nivolumab in patient with renal cell carcinoma inferior vena cava tumour thrombus

被引：9
作者：
Berends, Joel [1 ]
Gourley, Eric [1 ]
Kaushik, Dharam [1 ]
机构：
[1] Univ Texas Hlth, Dept Urol, San Antonio, TX 78229 USA
来源：
BMJ CASE REPORTS | 2019年 / 12卷 / 04期
关键词：
cancer intervention; immunological products and vaccines; urology; urological surgery; TARGETED MOLECULAR THERAPY; MANAGEMENT; TRENDS;
D O I：
10.1136/bcr-2018-227030
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 47-year-old previously healthy man presented with acute moderate flank pain. Evaluation revealed left renal cell carcinoma, with inferior vena cava tumour thrombus invasion. Patient had no significant history or risk factors to pre-dispose him to genitourinary cancers. Surgery was deemed to not be appropriate due to distant metastases, but patient received targeted molecular therapy and immunotherapy with striking regression of the thrombus.
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共 23 条
[1]   Check point inhibitors a new era in renal cell carcinoma treatment [J].
Alsharedi, Mohamed ;
Katz, Heather .
MEDICAL ONCOLOGY, 2018, 35 (06)
[2]  
[Anonymous], 2018, KLIN ONKOL, DOI DOI 10.14735/AMKO2018110
[3]   Rare Case of Intracardiac Renal Cell Carcinoma Metastasis with Response to Nivolumab: Case Report and Literature Review [J].
Ansari, Jawaher ;
Alhelali, Sumaya ;
Albinmousa, Zakariya ;
Farrag, Ashraf ;
Ali, Arwa M. ;
Abdelgelil, Mai ;
Alhamad, Abdulaziz ;
Alzahrani, Ghormallah ;
Ansari, Asif ;
Glaholm, John .
CASE REPORTS IN ONCOLOGY, 2018, 11 (03) :861-870
[4]   Neoadjuvant targeted molecular therapies in patients undergoing nephrectomy and inferior vena cava thrombectomy: is it useful? [J].
Bigot, Pierre ;
Fardoun, Tarek ;
Bernhard, Jean Christophe ;
Xylinas, Evanguelos ;
Berger, Julien ;
Roupret, Morgan ;
Beauval, Jean-Baptiste ;
Lagabrielle, Samuel ;
Lebdai, Souhil ;
Ammi, Myriam ;
Baumert, Herve ;
Escudier, Bernard ;
Grenier, Nicolas ;
Hetet, Jean-Francois ;
Long, Jean-Alexandre ;
Paparel, Philippe ;
Rioux-Leclercq, Nathalie ;
Soulie, Michel ;
Azzouzi, Abdel-Rahmene ;
Bensalah, Karim ;
Patard, Jean-Jacques .
WORLD JOURNAL OF UROLOGY, 2014, 32 (01) :109-114
[5]   Sunitinib or Sorafenib as Neoadjuvant Therapy May not Improve the Survival Outcomes of Renal Cell Carcinoma with Tumor Thrombus [J].
Cai, Wen ;
Huang, Jiwei ;
Yuan, Yichu ;
Hu, Xiaoyi ;
Li, Mingyang ;
Kong, Wen ;
Zhang, Jin ;
Guo, Jianming ;
Chen, Yonghui ;
Huang, Yiran .
UROLOGIA INTERNATIONALIS, 2018, 101 (04) :391-399
[6]   The Impact of Targeted Molecular Therapies on the Level of Renal Cell Carcinoma Vena Caval Tumor Thrombus [J].
Cost, Nicholas G. ;
Delacroix, Scott E., Jr. ;
Sleeper, Joshua P. ;
Smith, Paul J. ;
Youssef, Ramy F. ;
Chapin, Brian F. ;
Karam, Jose A. ;
Culp, Stephen ;
Abel, E. Jason ;
Brugarolas, James ;
Raj, Ganesh V. ;
Sagalowsky, Arthur I. ;
Wood, Christopher G. ;
Margulis, Vitaly .
EUROPEAN UROLOGY, 2011, 59 (06) :912-918
[7]   Neoadjuvant Sunitinib Decreases Inferior Vena Caval Thrombus Size and Is Associated With Improved Oncologic Outcomes: A Multicenter Comparative Analysis [J].
Field, Charles A. ;
Cotta, Brittney H. ;
Jimenez, Juan ;
Lane, Brian R. ;
Yim, Kendrick ;
Lee, Hak J. ;
Ryan, Stephen T. ;
Hamilton, Zachary A. ;
Patel, Sunil ;
Wang, Song ;
Kane, Christokher J. ;
Dey, Sumi ;
Mckay, Rana R. ;
Noyes, Sabrina ;
Millard, Frederick E. ;
Rini, Brian, I ;
Campbell, Steven C. ;
Derweesh, Ithaar H. .
CLINICAL GENITOURINARY CANCER, 2019, 17 (03) :E505-E512
[8]   Limited benefit of targeted molecular therapy for inferior vena cava thrombus associated with renal cell carcinoma [J].
Fukuda, Hironori ;
Kondo, Tsunenori ;
Takagi, Toshio ;
Iizuka, Jumpei ;
Nagashima, Yoji ;
Tanabe, Kazunari .
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2017, 22 (04) :767-773
[9]   Immunotherapy for renal cell carcinoma - current status [J].
Grimm, Marc-Oliver ;
Foller, Susan .
AKTUELLE UROLOGIE, 2018, 49 (02) :187-191
[10]   Updates to the Management of Kidney Cancer [J].
Jonasch, Eric .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2018, 16 (05) :639-641
123