Repeater F-waves in amyotrophic lateral sclerosis: Electrophysiologic indicators of upper or lower motor neuron involvement?

被引：22

作者：

Akarsu, Emel Oguz ^{[1
]}

Sirin, Nermin Gorkem ^{[1
]}

Orhan, Elif Kocasoy ^{[1
]}

Erbas, Bahar ^{[1
,2
]}

Dede, Hava Ozlem ^{[1
]}

Baslo, Mehmet Baris ^{[1
]}

Idrisoglu, Halil Atilla ^{[1
]}

Oge, Ali Emre ^{[1
]}

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34390 Istanbul, Turkey

[2] Demiroglu Bilim Univ, Fac Med, Dept Pharmacol, Istanbul, Turkey

来源：

CLINICAL NEUROPHYSIOLOGY | 2020年 / 131卷 / 01期

关键词：

Repeater F-wave; Amyotrophic lateral sclerosis; Triple stimulation technique; MScanFit MUNE; Transcranial magnetic stimulation; Split hand; TRANSCRANIAL MAGNETIC STIMULATION; UNIT NUMBER ESTIMATION; NEUROPHYSIOLOGICAL INDEX; SPINAL-CORD; DYSFUNCTION; PROGRESSION; INHIBITION; ALS; EXCITABILITY; SENSITIVITY;

D O I：

10.1016/j.clinph.2019.09.030

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To extract insight about the mechanism of repeater F-waves (Frep) by exploring their correlation with electrophysiologic markers of upper and lower motor neuron dysfunction in amyotrophic lateral sclerosis (ALS). Methods: The correlations of Frep parameters with clinical scores and the results of neurophysiological index (NI), MScanfit MUNE, F/M amplitude ratio (F/M%), single and paired-pulse transcranial magnetic stimulation (TMS), and triple stimulation technique (TST) studies, recorded from abductor digiti minimi (ADM) and abductor pollicis brevis (APB) muscles of 35 patients with ALS were investigated. Results: Frep parameters were correlated with NI and MScanfit MUNE in ADM muscle and F/M% in both muscles. None of the Frep parameters were correlated with clinical scores or TST and TMS measures. While the CMAP amplitudes were similar in the two recording muscles, there was a more pronounced decrease of F-wave persistence in APB, probably heralding the subsequent split hand phenomenon. Conclusion: Our findings suggest that the presence and density of Freps are primarily related to the degree of lower motor neuron loss and show no correlation with any of the relatively extensive set of parameters for upper motor neuron dysfunction. Significance: Freps are primarily related to lower motor neuron loss in ALS. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

引用

页码：96 / 105

页数：10

共 50 条

[31] Postural instability and lower extremity dysfunction in upper motor neuron-dominant amyotrophic lateral sclerosis [J].

Liu, Xiangyi ;

Chen, Lu ;

Ye, Shan ;

Liu, Xiaoxuan ;

Zhang, Yingshuang ;

Fan, Dongsheng .

FRONTIERS IN NEUROLOGY, 2024, 15

[32] The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis [J].

Castro, Jose ;

Swash, Michael ;

de Carvalho, Mamede .

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY, 2023, 53 (04)

[33] Upper motor neuron and extra-motor neuron involvement in amyotrophic lateral sclerosis: A clinical and brain imaging review [J].

van der Graaff, M. M. ;

de Jong, J. M. B. V. ;

Baas, F. ;

de Visser, M. .

NEUROMUSCULAR DISORDERS, 2009, 19 (01) :53-58

[34] Motor-evoked potentials in amyotrophic lateral sclerosis: potential implications in detecting subclinical UMN involvement in lower motor neuron phenotype [J].

Zoccolella, Stefano ;

Mastronardi, Antonella ;

Scarafino, Antonio ;

Iliceto, Giovanni ;

D'Errico, Eustachio ;

Fraddosio, Angela ;

Tempesta, Irene ;

Morea, Antonella ;

Scaglione, Gaspare ;

Introna, Alessandro ;

Simone, Isabella Laura .

JOURNAL OF NEUROLOGY, 2020, 267 (12) :3689-3695

[35] Motor neuron replacement therapy for amyotrophic lateral sclerosis [J].

Liu, Bochao ;

Li, Mo ;

Zhang, Lingyan ;

Chen, Zhiguo ;

Lu, Paul .

NEURAL REGENERATION RESEARCH, 2022, 17 (08) :1633-+

[36] Targeted assessment of lower motor neuron burden is associated with survival in amyotrophic lateral sclerosis [J].

Devine, Matthew S. ;

Ballard, Emma ;

O'Rourke, Peter ;

Kiernan, Matthew C. ;

Mccombe, Pamela A. ;

Henderson, Robert D. .

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION, 2016, 17 (3-4) :184-190

[37] Hyperreflexia as an upper motor neuron sign in amyotrophic lateral sclerosis [J].

Burke, David .

CLINICAL NEUROPHYSIOLOGY, 2019, 130 (08) :1405-1406

[38] Upper motor neuron assessment in amyotrophic lateral sclerosis using the patellar tendon reflex and motor-evoked potentials to the lower limbs [J].

Desmaison, A. ;

Truffert, A. ;

Pereira, B. ;

Camdessanche, J. -P. ;

Moisset, X. ;

Guy, N. .

REVUE NEUROLOGIQUE, 2024, 180 (07) :632-641

[39] Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis A Randomized Clinical Trial [J].

Wainger, Brian J. ;

Macklin, Eric A. ;

Vucic, Steve ;

McIlduff, Courtney E. ;

Paganoni, Sabrina ;

Maragakis, Nicholas J. ;

Bedlack, Richard ;

Goyal, Namita A. ;

Rutkove, Seward B. ;

Lange, Dale J. ;

Rivner, Michael H. ;

Goutman, Stephen A. ;

Ladha, Shafeeq S. ;

Mauricio, Elizabeth A. ;

Baloh, Robert H. ;

Simmons, Zachary ;

Pothier, Lindsay ;

Kassis, Sylvia Baedorf ;

La, Thuong ;

Hall, Meghan ;

Evora, Armineuza ;

Klements, David ;

Hurtado, Aura ;

Pereira, Joao D. ;

Koh, Joan ;

Celnik, Pablo A. ;

Chaudhry, Vinay ;

Gable, Karissa ;

Juel, Vern C. ;

Phielipp, Nicolas ;

Marei, Adel ;

Rosenquist, Peter ;

Meehan, Sean ;

Oskarsson, Bjorn ;

Lewis, Richard A. ;

Kaur, Divpreet ;

Kiskinis, Evangelos ;

Woolf, Clifford J. ;

Eggan, Kevin ;

Weiss, Michael D. ;

Berry, James D. ;

David, William S. ;

Davila-Perez, Paula ;

Camprodon, Joan A. ;

Pascual-Leone, Alvaro ;

Kiernan, Matthew C. ;

Shefner, Jeremy M. ;

Atassi, Nazem ;

Cudkowicz, Merit E. .

JAMA NEUROLOGY, 2021, 78 (02) :186-196

[40] Diffusion tensor MRI as a diagnostic tool of upper motor neuron involvement in amyotrophic lateral sclerosis [J].

Hong, YH ;

Lee, KW ;

Sung, JJ ;

Chang, KH ;

Song, IC .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2004, 227 (01) :73-78

← 1 2 3 4 5 →