Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases

被引：0

作者：

Dewit, O. ^{[1
]}

机构：

[1] St Luc Univ Hosp, Dept Gastroenterol, B-1200 Brussels, Belgium

来源：

ACTA GASTRO-ENTEROLOGICA BELGICA | 2010年 / 73卷 / 03期

关键词：

azathioprine; 6-thioguanine nucleotides (6-TGN); 6-methylmercaptopurine (6-MMP); thiopurine metabolism; thiopurine side effects; S-METHYLTRANSFERASE; CROHNS-DISEASE; AZATHIOPRINE THERAPY; COST-EFFECTIVENESS; TPMT ACTIVITY; PHARMACOGENETICS; 6-MERCAPTOPURINE; MERCAPTOPURINE; ALLOPURINOL; MYELOSUPPRESSION;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Thiopurines (TP) are widely used in the management of inflammatory bowel diseases. Side-effects and inefficacy are a major concern as they lead to withdrawal of the drug. Tools investigating TP metabolism are useful to avoid inadequate cessation of TP therapy. TP metabolism is complex and many enzymes are involved. Among them, Thiopurine methyltransferase (TPMT) is the only one routinely measured by pheno- or genotyping. In this review, the rationale for TPMT and thiopurine metabolites, 6-thioguanine nucleotides and 6-methylmercaptopurine, determination in clinical practice is discussed, specifically in case of thiopurine failure and recommendations are given about their interpretation and potential dose optimization of TP drugs. (Acta gastroenterolog. belg., 2010, 73, 331-335)

引用

页码：331 / 335

页数：5

共 50 条

[41] Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy? [J].

Sanderson, J ;

Ansari, A ;

Marinaki, T ;

Duley, J .

ANNALS OF CLINICAL BIOCHEMISTRY, 2004, 41 :294-302

[42] Thiopurine methyltransferase enzyme activity determination before treatment of inflammatory bowel disease with azathioprine: Effect on cost and adverse events [J].

Sayani, FA ;

Prosser, C ;

Bailey, RJ ;

Jacobs, P ;

Fedorak, RN .

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2005, 19 (03) :147-151

[43] Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants [J].

Schaeffeler, E ;

Fischer, C ;

Brockmeier, D ;

Wernet, D ;

Moerike, K ;

Eichelbaum, M ;

Zanger, UM ;

Schwab, M .

PHARMACOGENETICS, 2004, 14 (07) :407-417

[44]

SERREDEBEAUVAIS F, 1995, PRESSE MED, V24, P987

[45] Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine [J].

Sparrow, Miles P. ;

Hande, Scott A. ;

Friedman, Sonia ;

Cao, Dingcai ;

Hanauer, Stephen B. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2007, 5 (02) :209-214

[46]

Sparrow Miles P, 2009, Curr Gastroenterol Rep, V11, P496

[47] Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity [J].

Tai, HL ;

Krynetski, EY ;

Schuetz, EG ;

Yanishevski, Y ;

Evans, WE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) :6444-6449

[48]

WEINSHILBOUM RM, 1980, AM J HUM GENET, V32, P651

[49] Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease [J].

Winter, J ;

Walker, A ;

Shapiro, D ;

Gaffney, D ;

Spooner, RJ ;

Mills, PR .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2004, 20 (06) :593-599

[50] Thiopurine S-methyltransferase as a target for drug interactions [J].

Xin, HW ;

Fischer, C ;

Schwab, M ;

Klotz, U .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2005, 61 (5-6) :395-398

← 1 2 3 4 5 →