The clinical impact of the Covid-19 pandemic first wave on patients with cystic fibrosis in New York

被引：8

作者：

Simonson, Joseph L. ^{[1
]}

Esposito, Christine ^{[1
]}

Frantzen, Theresa ^{[1
]}

Henthorne, Katherine ^{[1
]}

Espinal, Aileen ^{[1
]}

Romano, Serena ^{[1
]}

Ramdeo, Ramona ^{[1
]}

Trentacoste, Jessica ^{[1
]}

Tsang, Donna ^{[1
]}

LaVecchia, Geralyn ^{[1
]}

Abdullah, Robert ^{[2
]}

Berdella, Maria ^{[3
]}

Bonitz, Lynn ^{[4
]}

Condos, Rany ^{[5
]}

Constantinescu, Andrei ^{[6
]}

DeCelie-Germana, Joan K. ^{[4
]}

DiMango, Emily ^{[7
]}

Draine, Myah ^{[5
]}

Gimeli, Tara ^{[4
]}

Giusti, Robert ^{[8
]}

Guzman, Jessenia ^{[7
]}

Hammouda, Soumia ^{[8
]}

Keating, Claire ^{[7
]}

Kier, Catherine ^{[9
]}

Lennox, Alison T. ^{[10
]}

Liriano, Carmen ^{[5
]}

Messer, Zachary ^{[10
]}

Plachta, Amy ^{[3
]}

Sadeghi, Hossein ^{[6
]}

Schwind, Elinor ^{[3
]}

Stables-Carney, Teresa ^{[2
]}

Walker, Patricia ^{[11
]}

Wang, Janice ^{[1
]}

机构：

[1] Hofstra Northwell, Div Pulm Crit Care & Sleep Med, Donald & Barbara Zucker Sch Med, New Hyde Pk, NY 11042 USA

[2] SUNY Stony Brook, Renaissance Sch Med, Dept Med, Stony Brook, NY 11794 USA

[3] Icahn Sch Med Mt Sinai, Div Pediat Pulmonol, Mt Sinai Beth Israel, New York, NY 10003 USA

[4] Hofstra Northwell, Div Pediat Pulmonol, Steven & Alexandra Cohen Childrens Med Ctr, Donald & Barbara Zucker Sch Med, Lake Success, NY 11042 USA

[5] New York Univ, Div Pulm Crit Care & Sleep Med, Grossman Sch Med, NYU Langone Hlth, New York, NY 10016 USA

[6] Columbia Univ, Div Pediat Pulmonol, Vagelos Coll Phys & Surg, Irving Med Ctr, New York, NY 10032 USA

[7] Columbia Univ, Div Pulm Allergy & Crit Care Med, Vagelos Coll Phys & Surg, Irving Med Ctr, New York, NY 10032 USA

[8] New York Univ, Div Pediat Pulm Med, NYU Langone Hlth, Grossman Sch Med, New York, NY 10016 USA

[9] SUNY Stony Brook, Renaissance Sch Med, Dept Pediat, Stony Brook, NY 11794 USA

[10] New York Med Coll, Div Pediat Pulmonol Allergy Immunol & Sleep Med, Valhalla, NY 10595 USA

[11] Icahn Sch Med Mt Sinai, Div Pulm Crit Care & Sleep Med, Mt Sinai Beth Israel, New York, NY 10003 USA

来源：

JOURNAL OF CYSTIC FIBROSIS | 2022年 / 21卷 / 03期

关键词：

Cystic fibrosis; Covid-19; SARS-CoV2; Coronavirus; ACE2; RECEPTOR;

D O I：

10.1016/j.jcf.2022.02.012

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: People with cystic fibrosis (pwCF) may be at risk of complications from COVID-19 but the impact of COVID-19 on pwCF remains unknown. Methods: We conducted a multicenter retrospective cohort study to assess the impact of the COVID-19 pandemic first wave on pwCF in the New York metropolitan area (NY) from March 1, 2020 to August 31, 2020. Objectives were to determine (1) the prevalence of COVID-19 by PCR and IgG antibody testing, (2) the clinical characteristics of COVID-19, (3) delay in routine outpatient care, and (4) the effect on anxiety and depression in pwCF. Results: There were 26 COVID-19 cases diagnosed by PCR or antibody testing among the study cohort of 810 pwCF. The prevalence of COVID-19 by PCR (1.6%) and IgG antibody (12.2%) testing was low. 58% of cases were asymptomatic and 82% were managed at home. 8% were hospitalized and 1 person died. 89% of pwCF experienced delay in care. The prevalence of anxiety increased from 43% baseline to 58% during the pandemic (P<0.01). In post-hoc analysis, the proportion of patients with diabetes (38% versus 16%, P<0.01) and pancreatic insufficiency (96% versus 66%, P<0.01) were higher while CFTR modulator use was lower (46% versus 65%, P = 0.05) in pwCF who tested positive for COVID-19. Conclusions: The prevalence of COVID-19 among pwCF in NY during the pandemic first wave was low and most cases were managed at home. CFTR modulators may be protective. PwCF experienced delay in routine care and increased anxiety. (c) 2022 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

引用

页码：E176 / E183

页数：8

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