The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia

被引：35

作者：

Gianni, Francesca ^{[1
]}

Belver, Laura ^{[1
]}

Ferrando, Adolfo ^{[1
,2
,3
]}

机构：

[1] Columbia Univ, Med Ctr, Inst Canc Genet, New York, NY 10032 USA

[2] Columbia Univ, Med Ctr, Dept Pathol, New York, NY 10032 USA

[3] Columbia Univ, Med Ctr, Dept Pediat, New York, NY 10032 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2020年 / 10卷 / 03期

关键词：

HEMATOPOIETIC STEM-CELLS; OF-FUNCTION MUTATIONS; ONCOGENIC TRANSCRIPTIONAL PROGRAM; SECRETASE INHIBITOR PF-03084014; DELTA-LIKE; TUMOR-SUPPRESSOR; C-MYC; CHROMOSOMAL TRANSLOCATION; HOMEOBOX GENE; TAL1; COMPLEX;

D O I：

10.1101/cshperspect.a035246

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and biological heterogeneity in this disease has already translated into new prognostic biomarkers, improved leukemia animal models, and emerging targeted therapies. This work reviews our current understanding of the molecular mechanisms of T-ALL.

引用

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