Antioxidant properties of some novel derivatives thiazolo[4,5-b] pyridine

被引：20

作者：

Chaban, Taras ^{[1
]}

Ogurtsov, Volodymyr ^{[1
]}

Mahlovanyy, Anatoliy ^{[2
]}

Sukhodolska, Natalia ^{[3
]}

Chaban, Ihor ^{[4
]}

Harkov, Stefan ^{[5
]}

Matiychuk, Vasyl ^{[6
]}

机构：

[1] Danylo Halytsky Lviv Natl Med Univ, Dept Gen Bioinorgan Phys & Colloidal Chem, Pekarska 69, UA-79010 Lvov, Ukraine

[2] Danylo Halytsky Lviv Natl Med Univ, Dept Phys Training & Sports Med, Pekarska 69, UA-79010 Lvov, Ukraine

[3] Danylo Halytsky Lviv Natl Med Univ, Dept Normal Physiol, Pekarska 69, UA-79010 Lvov, Ukraine

[4] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Chem FPGE, Pekarska 69, UA-79010 Lvov, Ukraine

[5] Burgas Univ Prof Dr Asen Zlatarov, Coll Med, Dept Pharm, St Stambolov 69 Blv, Burgas 8000, Bulgaria

[6] Ivan Franko Natl Univ Lviv, Dept Organ Chem, 6 Kyryla & Mefodia, UA-79005 Lvov, Ukraine

来源：

PHARMACIA | 2019年 / 66卷 / 04期

关键词：

antioxidant activity; 2,2 diphenyl-1-picrylhydrazyl; synthesis; thiazolo[4,5-b]pyridines; BIOLOGICAL-ACTIVITY; OXIDATIVE STRESS; FREE-RADICALS; METALS; QSAR;

D O I：

10.3897/pharmacia.66.e36764

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The synthesis and determination of the antioxidant activity of some novel (5,7-dimethyl-2-oxo-thiazolo[4,5-b]pyridine-3-yl)-acetic acid hydrazide derivatives are described in this article. The transformation of the base heterocycle was carried out via the reactions of acylation, [2+3]cyclocondensation, Knoevenagel condencation and alkylation for the purpose to obtain substances with a satisfactory pharmacological profile. Antioxidant activity of the synthesized compounds was evaluated in vitro by means of the scavenging metod effect on 2,2 diphenyl-1-picrylhydrazyl (DPPH) radicals. [GRAPHICS]

引用

页码：171 / 180

页数：10

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