Synthesis, characterization, and antioxidant and anticholinesterase activities of pyrazolo derivatives

被引：4

作者：

Sicak, Yusuf ^{[1
]}

Oruc-Emre, Emine E. ^{[2
]}

Ozturk, Mehmet ^{[3
]}

Karakucuk-Iyidogan, Aysegul ^{[2
]}

Nadeem, Said ^{[4
]}

机构：

[1] Mugla Sitki Kocman Univ, Koycegiz Vocat Sch, Dept Med & Aromat Plants, TR-48800 Mugla, Turkey

[2] Gaziantep Univ, Fac Sci & Arts, Dept Chem, Gaziantep, Turkey

[3] Mugla Sitki Kocman Univ, Fac Sci, Dept Chem, Mugla, Turkey

[4] Adnan Menderes Univ, Kosk Vocat Sch, Dept Food Proc, Aydin, Turkey

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 02期

关键词：

MORPHOLINE; ANTIBACTERIAL; ANTAGONISTS;

D O I：

10.1002/jhet.3829

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Twenty-four pyrazolo derivatives (1-4)(a-f) were synthesized and characterized by FTIR, H-1, and C-13 NMR (Nuclear Magnetic Resonance), and elemental analysis. The synthesized compounds were also investigated for their antioxidant and anticholinesterase activities. The compounds (3-4)(a-f) carrying morpholine ring were more active than the piperidinyl containing compounds (1-2)(a-f) in both activities. The compound 4f showed higher activity in both assays as compared with the others. Additionally, the anticholinesterase activity test provided higher values than the galantamine in the BChE assay. Therefore, compound 4f can be used as anticholinesterase agent and/or anticholinesterase assay standard.

引用

页码：830 / 841

页数：12

共 31 条

[1] Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives
Akbas, E
Berber, I
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2005, 40 (04) : 401 - 405
[2] Andrews S. W., 2018, U.S. Patent Application, Patent No. [10/174,028, 10174028]
[3] Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine:: CUPRAC method
Apak, R
Güçlu, K
Özyürek, M
Karademir, SE
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (26) : 7970 - 7981
[4] A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives
Aridoss, Gopalakrishnan
Amirthaganesan, Shanmugasundaram
Kumar, Nanjundan Ashok
Kim, Jong Tae
Lim, Kwon Taek
Kabilan, Senthamaraikannan
Jeong, Yeon Tae
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (24) : 6542 - 6548
[5] ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL
BLOIS, MS
[J]. NATURE, 1958, 181 (4617) : 1199 - 1200
[6] Synthesis and aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones
Bruno, G
Costantino, L
Curinga, C
Maccari, R
Monforte, F
Nicolò, F
Ottanà, R
Vigorita, MG
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (04) : 1077 - 1084
[7] Cain G. A., 1992, U.S. Patent, Patent No. [5,169,855, 5169855]
[8] CHEN W, 2010, Patent No. 7718662
[9] Hypocholesterolemic and hypolipidemic activity of some novel morpholine derivatives with antioxidant activity
Chrysselis, MC
Rekka, EA
Kourounakis, PN
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (04) : 609 - 612
[10] Daniel T, 2007, US Patent, Patent No. 7183360

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