Rcs and PhoPQ regulatory overlap in the control of Salmonella enterica virulence

被引：55

作者：

Garcia-Calderon, Clara B. ^{[1
]}

Casadesus, Josep ^{[1
]}

Ramos-Morales, Francisco ^{[1
]}

机构：

[1] Univ Seville, Fac Biol, Dept Genet, E-41080 Seville, Spain

来源：

JOURNAL OF BACTERIOLOGY | 2007年 / 189卷 / 18期

关键词：

D O I：

10.1128/JB.00640-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genetic screens based on the use of MudJ-generated lac fusions permitted the identification of novel genes regulated by the Res signal transduction system in Salmonella enterica serovar Typhimurium. Besides genes that are also found in the Escherichia coli genome, our screens identified Salmonella-specific genes regulated by RcsB, including bapA, siiE, srfA, and srfB. Here we show that the srfABC operon is negatively regulated by RcsB and by PhoP. In vivo studies using mutants with constitutive activation of the Res and/or PhoPQ system suggested that there is an overlap between these regulatory systems in the control of Salmonella virulence.

引用

页码：6635 / 6644

页数：10

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