Brain cholesterol in normal and pathological aging

被引：128

作者：

Martin, Mauricio ^{[2
,3
]}

Dotti, Carlos G. ^{[1
,2
,3
]}

Dolores Ledesma, Maria ^{[1
]}

机构：

[1] CSIC UAM, CBMSO, Madrid 28049, Spain

[2] VIB, Dept Mol & Dev Gener, B-3000 Louvain, Belgium

[3] Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2010年 / 1801卷 / 08期

关键词：

Cholesterol; aging; Alzheimer's disease; CYP46; brain; DENSITY-LIPOPROTEIN RECEPTOR; CENTRAL-NERVOUS-SYSTEM; APOLIPOPROTEIN-E KNOCKOUT; TRANSGENIC MOUSE MODEL; LONG-TERM POTENTIATION; E-DEFICIENT MICE; HMG-COA REDUCTASE; ALZHEIMERS-DISEASE; A-BETA; GENE-EXPRESSION;

D O I：

10.1016/j.bbalip.2010.03.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Correct lipid homeostasis at the plasma membrane is essential for cell survival and performance. These are critically challenged in the aging brain. Changes in the levels of cholesterol, a major membrane component especially enriched in neurons, accompany the brain aging process. They also occur in neurodegenerative diseases. Understanding the causes and consequences of these changes is a crucial step when trying to delay the cognitive decline, which comes with age, or to design strategies to fight neurodegenerative disorders such as Alzheimer's disease. We here review work that has contributed to this understanding. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：934 / 944

页数：11