Brain cholesterol in normal and pathological aging

被引：131

作者：

Martin, Mauricio ^{[2
,3
]}

Dotti, Carlos G. ^{[1
,2
,3
]}

Dolores Ledesma, Maria ^{[1
]}

机构：

[1] CSIC UAM, CBMSO, Madrid 28049, Spain

[2] VIB, Dept Mol & Dev Gener, B-3000 Louvain, Belgium

[3] Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2010年 / 1801卷 / 08期

关键词：

Cholesterol; aging; Alzheimer's disease; CYP46; brain; DENSITY-LIPOPROTEIN RECEPTOR; CENTRAL-NERVOUS-SYSTEM; APOLIPOPROTEIN-E KNOCKOUT; TRANSGENIC MOUSE MODEL; LONG-TERM POTENTIATION; E-DEFICIENT MICE; HMG-COA REDUCTASE; ALZHEIMERS-DISEASE; A-BETA; GENE-EXPRESSION;

D O I：

10.1016/j.bbalip.2010.03.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Correct lipid homeostasis at the plasma membrane is essential for cell survival and performance. These are critically challenged in the aging brain. Changes in the levels of cholesterol, a major membrane component especially enriched in neurons, accompany the brain aging process. They also occur in neurodegenerative diseases. Understanding the causes and consequences of these changes is a crucial step when trying to delay the cognitive decline, which comes with age, or to design strategies to fight neurodegenerative disorders such as Alzheimer's disease. We here review work that has contributed to this understanding. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：934 / 944

页数：11

共 188 条

[61] THE BIOSYNTHESIS OF POLYISOPRENOID CHAINS [J].

HEMMING, FW .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1983, 11 (05) :497-504

[62] Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease [J].

Heverin, M ;

Bogdanovic, N ;

Lütjohann, D ;

Bayer, T ;

Pikuleva, I ;

Bretillon, L ;

Diczfalusy, U ;

Winblad, B ;

Björkhem, I .

JOURNAL OF LIPID RESEARCH, 2004, 45 (01) :186-193

[63] Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation [J].

Hiesberger, T ;

Trommsdorff, M ;

Howell, BW ;

Goffinet, A ;

Mumby, MC ;

Cooper, JA ;

Herz, J .

NEURON, 1999, 24 (02) :481-489

[64] Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain [J].

Hirsch-Reinshagen, V ;

Zhou, S ;

Burgess, BL ;

Bernier, L ;

McIsaac, SA ;

Chan, JY ;

Tansley, GH ;

Cohn, JS ;

Hayden, MR ;

Wellington, CL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (39) :41197-41207

[65] The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease [J].

Hutter-Paier, B ;

Huttunen, HJ ;

Puglielli, L ;

Eckman, CB ;

Kim, DY ;

Hofmeister, A ;

Moir, RD ;

Domnitz, SB ;

Frosch, MP ;

Windisch, M ;

Kovacs, DM .

NEURON, 2004, 44 (02) :227-238

[66] Rescuing troubled vessels in Alzheimer disease [J].

Iadecola, C .

NATURE MEDICINE, 2005, 11 (09) :923-924

[67]

Igbavboa U, 1997, J NEUROCHEM, V69, P1661

[68] An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha [J].

Janowski, BA ;

Willy, PJ ;

Devi, TR ;

Falck, JR ;

Mangelsdorf, DJ .

NATURE, 1996, 383 (6602) :728-731

[69] Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages [J].

Jessup, Wendy ;

Gelissen, Ingrid C. ;

Gaus, Katharina ;

Kritharides, Leonard .

CURRENT OPINION IN LIPIDOLOGY, 2006, 17 (03) :247-257

[70] The effects of aging on gene expression in the hypothalamus and cortex of mice [J].

Jiang, CH ;

Tsien, JZ ;

Schultz, PG ;

Hu, YH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) :1930-1934

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