Initial interaction of osteoblasts with the surface of a hydroxyapatite-poly(methylmethacrylate) cement

被引：103
作者：
Dalby, MJ
Di Silvio, L
Harper, EJ
Bonfield, W
机构：
[1] Inst Orthopaed, IRC Biomed Mat, Stanmore HA7 4LP, Middx, England
[2] Queen Mary Univ London, IRC Biomed Mat, London E1 4NS, England
[3] Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 3QZ, England
来源：
BIOMATERIALS | 2001年 / 22卷 / 13期
基金：
英国工程与自然科学研究理事会;
关键词：
bone cement; hydroxyapatite; osteoblasts; cell culture; topography;
D O I：
10.1016/S0142-9612(00)00334-3
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Failure of the bone/cement interface in cemented joint prostheses is a contributor to implant loosening. The introduction of a bioactive phase, such as hydroxyapatite (WA), to cement may enhance fixation by encouraging direct bone apposition rather than encapsulation of the implant by fibrous tissue. The effect of poly(methylmehacrylate) (PMMA) bone cement (incorporating 17.5% HA wt.) on bioactivity has been investigated using primary human osteoblast-like cells (HOB). A significantly higher cell proliferation and differentiation was seen on the PMMA/HA cement compared to the PMMA cement alone, with retention of phenotype up to 21 days of culture on both materials. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1739 / 1747
页数：9
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