Soluble Urokinase Plasminogen Activator Receptor: A New Biomarker in the Pediatric Intensive Care Unit

被引:9
作者
El-Mekkawy, Muhammad S. [1 ]
Saleh, Nagwan Y. [1 ]
Sonbol, Ahmed A. [2 ]
机构
[1] Menoufia Univ, Dept Pediat, Menoufia, Egypt
[2] Menoufia Univ, Dept Clin Pathol, Menoufia, Egypt
关键词
Soluble urokinase plasminogen activator receptor; Sepsis biomarker; Intensive care unit; Children; Systemic inflammatory response syndrome; PROGNOSTIC BIOMARKER; PREDICTS MORTALITY; SUPAR; NEUTROPHILS; INFECTIONS; MIGRATION; COMMUNITY; CHILDREN; SEPSIS;
D O I
10.1007/s12098-016-2063-9
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective To evaluate the value of soluble urokinase plasminogen activator receptor (suPAR) in diagnosing sepsis and predicting mortality in critically ill children. Methods In a prospective cohort study, 69 critically ill children admitted into the pediatric intensive care unit (PICU) were randomly enrolled in addition to 15 healthy children as a control group. Clinical examination was performed, including calculation of the Pediatric Risk of Mortality (PRISM) and Pediatric Index of Mortality2 (PIM2). suPAR was measured in patients at admission as well as in the controls. Patients were followed up for 30 d. Results suPAR level was significantly higher among the total patient cohort compared to controls (p < 0.0001). suPAR was also significantly higher among patients with sepsis compared to both controls (p < 0.0001) and patients without sepsis (p < 0.0001). Furthermore, suPAR level was significantly elevated in non-survivors compared to survivors (p 0.008). Receiver operating characteristic curve (ROC curve) analysis revealed an area under the curve (AUC) of 0.80 for suPAR for diagnosis of sepsis while C-reactive protein (CRP) had an AUC of 0.82. Regarding the prognosis, suPAR had an AUC of 0.69 for prediction of mortality, whereas the AUC for PRISM, PIM2, and CRP were 0.82, 0.81, and 0.77 respectively. Conclusions suPAR has both a diagnostic and a prognostic value for critically ill children. However, it does not seem to be superior to the classic laboratory markers and clinical scoring systems.
引用
收藏
页码:661 / 669
页数:9
相关论文
共 23 条
  • [11] Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study
    Kofoed, Kristian
    Andersen, Ove
    Kronborg, Gitte
    Tvede, Michael
    Petersen, Janne
    Eugen-Olsen, Jesper
    Larsen, Klaus
    [J]. CRITICAL CARE, 2007, 11 (02)
  • [12] Biomarkers and Molecular Analysis to Improve Bloodstream Infection Diagnostics in an Emergency Care Unit
    Loonen, Anne J. M.
    de Jager, Cornelis P. C.
    Tosserams, Janna
    Kusters, Ron
    Hilbink, Mirrian
    Wever, Peter C.
    van den Brule, Adriaan J. C.
    [J]. PLOS ONE, 2014, 9 (01):
  • [13] uPAR-induced cell adhesion and migration: vitronectin provides the key
    Madsen, Chris D.
    Ferraris, Gian Maria Sarra
    Andolfo, Annapaola
    Cunningham, Orla
    Sidenius, Nicolai
    [J]. JOURNAL OF CELL BIOLOGY, 2007, 177 (05) : 927 - 939
  • [14] Serum levels of soluble urokinase plasminogen activator receptor is associated with parasitemia in children with acute Plasmodium falciparum malaria infection
    Perch, M
    Kofoed, P
    Fischer, TK
    Có, F
    Rombo, L
    Aaby, P
    Eugen-Olsen, J
    [J]. PARASITE IMMUNOLOGY, 2004, 26 (05) : 207 - 211
  • [15] Release of the Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) by Activated Neutrophils in Rheumatoid Arthritis
    Pliyev, Boris K.
    Menshikov, Mikhail Yu.
    [J]. INFLAMMATION, 2010, 33 (01) : 1 - 9
  • [16] PEDIATRIC RISK OF MORTALITY (PRISM) SCORE
    POLLACK, MM
    RUTTIMANN, UE
    GETSON, PR
    [J]. CRITICAL CARE MEDICINE, 1988, 16 (11) : 1110 - 1116
  • [17] Pediatric sepsis Important considerations for diagnosing and managing severe infections in infants, children, and adolescents
    Randolph, Adrienne G.
    McCulloh, Russell J.
    [J]. VIRULENCE, 2014, 5 (01) : 179 - 189
  • [18] Clinical Value of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor Levels in Term Neonates with Infection or Sepsis: A Prospective Study
    Siahanidou, Tania
    Margeli, Alexandra
    Tsirogianni, Chrysanthi
    Charoni, Stavroula
    Giannaki, Maria
    Vavourakis, Eustathios
    Charisiadou, Athina
    Papassotiriou, Ioannis
    [J]. MEDIATORS OF INFLAMMATION, 2014, 2014
  • [19] PIM2: a revised version of the Paediatric Index of Mortality
    Slater, A
    Shann, F
    Pearson, G
    [J]. INTENSIVE CARE MEDICINE, 2003, 29 (02) : 278 - 285
  • [20] Thuno M, 2009, DIS MARKERS, V27, P157, DOI [10.1155/2009/504294, 10.3233/DMA-2009-0657]