Hypogonadotropic hypogonadism in Klinefelter syndrome and hypothalamic-pituitary tumor

被引：0

作者：

Beisti Ortego, Anunciacion ^{[1
]}

De Arriba Munoz, Antonio ^{[1
]}

Lozano, Marta Ferrer ^{[1
]}

de Zabarte Fernandez, Jose Miguel Martinez ^{[1
]}

Calvo Escribano, Carlota ^{[1
]}

Labarta Aizpun, Jose Ignacio ^{[1
]}

机构：

[1] Hosp Univ Miguel Servet, Zaragoza, Spain

来源：

ARCHIVOS ARGENTINOS DE PEDIATRIA | 2015年 / 113卷 / 01期

关键词：

Klinefelter Syndrome; hypogonadism; germ cell tumors; GERM-CELL TUMORS; CANCER INCIDENCE; MEN; ASSOCIATION;

D O I：

10.5546/aap.2015.e6

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Klinefelter Syndrome is the most frequent cause of hypergonadotropic hypogonadism in men. A flat response at luteinizing hormone releasing hormone stimulation test could be the first sign of hypothalamic tumor in these patients. We report the case of a patient diagnosed by neonatal screening with Klinefelter Syndrome, 47 XXY, that at 17 years follow-up presents analytical modification of the response to luteinizing hormone releasing hormone stimulation test with suppressed luteinizing hormone and follicle-stimulating hormone values; lately he presents with headache and loss of left eye vision. A magnetic resonance imaging of the brain showed a mixed germ cell hypothalamus tumor, requiring surgery, chemotherapy and radiotherapy with optimal response.

引用

页码：E6 / E9

页数：4

共 50 条

[21] Klinefelter syndrome and medical treatment: Hypogonadism and beyond
Chang S.
Skakkebæk A.
Gravholt C.H.
Hormones, 2015, 14 (4) : 531 - 548
[22] Serum insulin-like factor 3 quantification by LC–MS/MS in male patients with hypogonadotropic hypogonadism and Klinefelter syndrome
Trine Holm Johannsen
Marie Lindhardt Ljubicic
Jacques Young
Séverine Trabado
Jørgen Holm Petersen
Allan Linneberg
Jakob Albrethsen
Anders Juul
Endocrine, 2021, 71 : 578 - 585
[23] Hypogonadotropic hypogonadism due to IHH or Kallmann syndrome in males
Behre, H. M.
Tuettelmann, F.
Ledig, S.
Wieacker, P.
MEDIZINISCHE GENETIK, 2011, 23 (02) : 254 - 258
[24] Congenital Idiopathic Hypogonadotropic Hypogonadism: Evidence of Defects in the Hypothalamus, Pituitary, and Testes
Sykiotis, Gerasimos P.
Hoang, Xuan-Huong
Avbelj, Magdalena
Hayes, Frances J.
Thambundit, Apisadaporn
Dwyer, Andrew
Au, Margaret
Plummer, Lacey
Crowley, William F., Jr.
Pitteloud, Nelly
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (06) : 3019 - 3027
[25] Klinefelter syndrome (KS): genetics, clinical phenotype and hypogonadism
Bonomi, M.
Rochira, V.
Pasquali, D.
Balercia, G.
Jannini, E. A.
Ferlin, A.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2017, 40 (02): : 123 - 134
[26] Klinefelter syndrome (KS): genetics, clinical phenotype and hypogonadism
M. Bonomi
V. Rochira
D. Pasquali
G. Balercia
E. A. Jannini
A. Ferlin
Journal of Endocrinological Investigation, 2017, 40 : 123 - 134
[27] BILATERAL DUANES SYNDROME ASSOCIATED WITH HYPOGONADOTROPIC HYPOGONADISM AND ANOSMIA (KALLMANNS SYNDROME)
CORDONNIER, M
VANNECHEL, C
HANOZET, V
FERRY, F
ABERKANE, J
NEURO-OPHTHALMOLOGY, 1992, 12 (01) : 17 - 24
[28] Serum insulin-like factor 3 quantification by LC-MS/MS in male patients with hypogonadotropic hypogonadism and Klinefelter syndrome
Johannsen, Trine Holm
Ljubicic, Marie Lindhardt
Young, Jacques
Trabado, Severine
Petersen, Jorgen Holm
Linneberg, Allan
Albrethsen, Jakob
Juul, Anders
ENDOCRINE, 2021, 71 (03) : 578 - 585
[29] Congenital Hypogonadotropic Hypogonadism and Kallmann Syndrome: Past, Present, and Future
Kim, Soo-Hyun
ENDOCRINOLOGY AND METABOLISM, 2015, 30 (04) : 456 - 466
[30] Efficacy of Pulsatile Gonadotropin-Releasing Hormone Therapy in Male Patients: Comparison between Pituitary Stalk Interruption Syndrome and Congenital Hypogonadotropic Hypogonadism
Huang, Qibin
Mao, Jiangfeng
Wang, Xi
Yu, Bingqing
Ma, Wanlu
Ji, Wen
Zhu, Yiyi
Zhang, Rui
Sun, Bang
Zhang, Junyi
Nie, Min
Wu, Xueyan
ENDOCRINE PRACTICE, 2022, 28 (05) : 521 - 527

← 1 2 3 4 5 →