Lymphoid Tissue Collagen Deposition in HIV-Infected Patients Correlates With the Imbalance Between Matrix Metalloproteinases and Their Inhibitors

被引：16

作者：

Diaz, Alba ^{[1
]}

Garcia, Felipe ^{[2
]}

Mozos, Anna ^{[1
]}

Caballero, Miguel ^{[3
]}

Leon, Agathe ^{[2
]}

Martinez, Antonio ^{[1
]}

Gil, Cristina ^{[4
]}

Plana, Montserrat ^{[4
]}

Gallart, Teresa ^{[5
]}

Gatell, Jose M. ^{[2
]}

Alos, Llucia ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin Barcelona, IDIBAPS, Dept Pathol, E-08036 Barcelona, Spain

[2] Univ Barcelona, Hosp Clin Barcelona, IDIBAPS, Dept Infect Dis, E-08036 Barcelona, Spain

[3] Univ Barcelona, Hosp Clin Barcelona, IDIBAPS, Dept Otolaryngol, E-08036 Barcelona, Spain

[4] Univ Barcelona, Hosp Clin Barcelona, IDIBAPS, Retrovirol & Viral Immunopathol Labs, E-08036 Barcelona, Spain

[5] Univ Barcelona, Hosp Clin Barcelona, IDIBAPS, Immunol Lab, E-08036 Barcelona, Spain

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 06期

关键词：

VIRAL BURDEN; T-CELLS; EXPRESSION; FIBROSIS;

D O I：

10.1093/infdis/jiq129

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the lymphoid tissue biopsies of 20 patients with chronic human immunodeficiency virus (HIV) infection by analyzing collagen deposition, CD4+ cell number, and gene expression of metalloproteinases (MMPs; MMP-2, MMP-9) and tissue inhibitors of MMPs (TIMPs; TIMP-1, TIMP-2). HIV-infected patients had significantly increased collagen deposition (P=.001), fewer CD4+ T cells (P=.05), and decreased MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios (P=.01), compared with HIV-negative control patients. Moreover, we found a significant negative correlation between collagen deposition and the MMP-9/TIMP-1 ratio (rho=-0.50; P=.047). To our knowledge, this is the first time that MMP/TIMP imbalance has been correlated with lymphoid tissue collagen deposition and incomplete immune recovery in HIV-infected patients, even after long-term antiretroviral treatment.

引用

页码：810 / 813

页数：4

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