A New Series of 1,3,4-Oxadiazole Linked Quinolinyl-Pyrazole/Isoxazole Derivatives: Synthesis and Biological Activity Evaluation

被引：4
|
作者：
Basavanna, V [1 ]
Chandramouli, M. [1 ]
Kempaiah, C. [2 ]
Bhadraiah, U. K. [3 ]
Chandra [4 ]
Lingegowda, N. S. [1 ]
Doddamani, Shridevi [5 ]
Ningaiah, S. [1 ]
机构：
[1] Visvesvaraya Technol Univ, Vidyavardhaka Coll Engn, Dept Chem, Mysore 570002, Karnataka, India
[2] HKBK Coll Engn, Dept Engn Phys, Bengaluru 560045, Karnataka, India
[3] Univ Mysore, Yuvarajas Coll, Dept Chem, Mysore 570005, Karnataka, India
[4] Natl Inst Engn NIE, Dept Phys, Mysore 570008, Karnataka, India
[5] CSIR NIIST, Chem Sci & Technol Div, Thiruvananthapuram 695019, Kerala, India
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2021年 / 91卷 / 11期
关键词：
1; 3; 4-oxadiazole; pyrazole; isoxazole; quinoline; molecular docking; antimicrobial; anti-inflammatory;
D O I：
10.1134/S1070363221110128
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 1,3,4-oxadiazole bridged pyrazole/isoxazole bearing quinoline derivatives has been designed and synthesized by a clean and convenient method. Structures of the newly synthesized compounds have been confirmed by FTIR, H-1 and C-13 NMR, and HRMS spectral data. The titled compounds have been evaluated for their molecular docking guided antimicrobial and anti-inflammatory activity. One of 1,3,4-oxadiazole bridged quinolinyl-pyrazole derivatives has interacted efficiently with E. Coli protein (PDB file: 1KZN), and has been characterized by good antimicrobial activity against the majority of the tested pathogens. Another product has exhibited excellent anti-inflammatory activity.
引用
收藏
页码：2257 / 2266
页数：10
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