The role of transcriptional control in multiple system atrophy

Multiple system atrophy (MSA) is an alpha-synucleinopathy that is clinically characterized by varying degrees of parkinsonian, autonomic, and cerebellar features. Unlike other alpha-synucleinopathies such as Parkinson's disease, MSA is unique in that the principal alpha-synuclein lesions, called glial cytoplasmic inclusions, occur in oligodendroglia rather than neurons, with significantly more alpha-synuclein accumulating in MSA brain compared with Parkinson's disease. Although well defined clinically, the molecular pathophysiology of MSA has barely been investigated. In particular, there have been no systematic studies of the perturbation of the brain transcriptome during the onset and progression of this disease. Interestingly, measurements of alpha-synuclein gene (SNCA) expression in MSA brain tissue have not revealed overexpression of this gene in oligodendroglia or neurons. It has therefore become clear that other genes and gene networks, both directly as noncoding RNAs or through protein products, contribute to the accumulation of the a-synuclein protein in the brain. This review provides a summary of current developments in the investigation of the transcriptional causes of MSA and outlines perspectives for future research toward the elucidation of the molecular pathology of MSA-specific neurodegeneration. (C) 2015 Elsevier Inc. All rights reserved.