Weak Chelation-Assisted C4-Selective Alkylation of Indoles with Cyclopropanols via Sequential C-H/C-C Bond Activation

被引：25

作者：

Paul, Tripti ^{[1
]}

Basak, Shubhajit ^{[1
]}

Punniyamurthy, Tharmalingam ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 32期

关键词：

H FUNCTIONALIZATION; ARYLATION; ALKALOIDS; REGIOCONTROL; STRATEGIES; CHEMISTRY;

D O I：

10.1021/acs.orglett.2c02265

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Rh-catalyzed weak chelation-guided C4-alkylation of indoles has been accomplished using cyclopropanols as an alkylating agent via the cascade C-H and C-C bond activation. The substrate scope, functional group tolerance, and late-stage mutation of drug molecules are the important practical features.

引用

页码：6000 / 6005

页数：6

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