Small-Molecule Modulation of Protein Homeostasis

被引：218
作者：
Burslem, George M.
Crews, Craig M. [1 ]
机构：
[1] Yale Univ, Dept Mol Cellular & Dev Biol, 219 Prospect St, New Haven, CT 06511 USA
来源：
CHEMICAL REVIEWS | 2017年 / 117卷 / 17期
关键词：
UBIQUITIN-ACTIVATING ENZYME; TRANSMEMBRANE CONDUCTANCE REGULATOR; MULTIPLE-MYELOMA CELLS; AMYLOID FIBRIL FORMATION; ESTROGEN-RECEPTOR-ALPHA; NF-KAPPA-B; PROTEASOME-MEDIATED DEGRADATION; OVERCOMES BORTEZOMIB RESISTANCE; ADVANCED PROSTATE-CANCER; LIGAND HYBRID MOLECULES;
D O I：
10.1021/acs.chemrev.7b00077
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with small molecules and compare the various systems available.
引用
收藏
页码：11269 / 11301
页数：33
相关论文
共 333 条
  • [1] The proteasome: structure, function, and role in the cell
    Adams, J
    [J]. CANCER TREATMENT REVIEWS, 2003, 29 : 3 - 9
  • [2] The proteasome: A suitable antineoplastic target
    Adams, J
    [J]. NATURE REVIEWS CANCER, 2004, 4 (05) : 349 - 360
  • [3] RNA interference: Biology, mechanism, and applications
    Agrawal, N
    Dasaradhi, PVN
    Mohmmed, A
    Malhotra, P
    Bhatnagar, RK
    Mukherjee, SK
    [J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2003, 67 (04) : 657 - +
  • [4] Miglustat (NB-DNJ) works as a chaperone for mutated acid β-glucosidase in cells transfected with several Gaucher disease mutations
    Alfonso, P
    Pampín, S
    Estrada, J
    Rodríguez-Rey, JC
    Giraldo, P
    Sancho, J
    Pocoví, M
    [J]. BLOOD CELLS MOLECULES AND DISEASES, 2005, 35 (02) : 268 - 276
  • [5] Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes
    Altun, Mikael
    Kramer, Holger B.
    Willems, Lianne I.
    McDermott, Jeffrey L.
    Leach, Craig A.
    Goldenberg, Seth J.
    Kumar, K. G. Suresh
    Konietzny, Rebecca
    Fischer, Roman
    Kogan, Edward
    Mackeen, Mukram M.
    McGouran, Joanna
    Khoronenkova, Svetlana V.
    Parsons, Jason L.
    Dianov, Grigory L.
    Nicholson, Benjamin
    Kessler, Benedikt M.
    [J]. CHEMISTRY & BIOLOGY, 2011, 18 (11): : 1401 - 1412
  • [6] An inhibitor of ubiquitin conjugation and aggresome formation
    An, Heeseon
    Statsyuk, Alexander V.
    [J]. CHEMICAL SCIENCE, 2015, 6 (09) : 5235 - 5245
  • [7] Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems
    An, Wenlin
    Jackson, Rachel E.
    Hunter, Paul
    Goegel, Stefanie
    van Diepen, Michiel
    Liu, Karen
    Meyer, Martin P.
    Eickholt, Britta J.
    [J]. PLOS ONE, 2015, 10 (12):
  • [8] Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis
    Anderson, Daniel J.
    Le Moigne, Ronan
    Djakovic, Stevan
    Kumar, Brajesh
    Rice, Julie
    Wong, Steve
    Wang, Jinhai
    Yao, Bing
    Valle, Eduardo
    von Soly, Szerenke Kiss
    Madriaga, Antonett
    Soriano, Ferdie
    Menon, Mary-Kamala
    Wu, Zhi Yong
    Kampmann, Martin
    Chen, Yuwen
    Weissman, Jonathan S.
    Aftab, Blake T.
    Yakes, F. Michael
    Shawver, Laura
    Zhou, Han-Jie
    Wustrow, David
    Rolfe, Mark
    [J]. CANCER CELL, 2015, 28 (05) : 653 - 665
  • [9] E3 ubiquitin ligases
    Ardley, HC
    Robinson, PA
    [J]. ESSAYS IN BIOCHEMISTRY, VOL 41: THE UBIQUITIN-PROTEASOME SYSTEM, 2005, 41 : 15 - 30
  • [10] An FKBP destabilization domain modulates protein levels in Plasmodium falciparum
    Armstrong, Christopher M.
    Goldberg, Daniel E.
    [J]. NATURE METHODS, 2007, 4 (12) : 1007 - 1009
12345678910