Small-Molecule Modulation of Protein Homeostasis

被引：223

作者：

Burslem, George M.

Crews, Craig M. ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, 219 Prospect St, New Haven, CT 06511 USA

来源：

CHEMICAL REVIEWS | 2017年 / 117卷 / 17期

关键词：

UBIQUITIN-ACTIVATING ENZYME; TRANSMEMBRANE CONDUCTANCE REGULATOR; MULTIPLE-MYELOMA CELLS; AMYLOID FIBRIL FORMATION; ESTROGEN-RECEPTOR-ALPHA; NF-KAPPA-B; PROTEASOME-MEDIATED DEGRADATION; OVERCOMES BORTEZOMIB RESISTANCE; ADVANCED PROSTATE-CANCER; LIGAND HYBRID MOLECULES;

D O I：

10.1021/acs.chemrev.7b00077

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Control of protein levels by nucleic-acid-based technologies has proven to be a useful research tool but lacks the advantages of small molecules with respect to cell permeability, temporal control, and the potential generation of therapeutics. In this Review, we discuss the technologies available for the control of intracellular protein levels with small molecules and compare the various systems available.

引用

页码：11269 / 11301

页数：33

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