A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles

被引：13

作者：

Cabrera, Flavio C. ^{[1
]}

Melo, Antonio F. A. A. ^{[2
]}

de Souza, Joao C. P. ^{[2
]}

Job, Aldo E. ^{[1
]}

Crespilho, Frank N. ^{[2
]}

机构：

[1] UNESP, FCT, Dept Fis Quim & Biol, Presidente Prudente, SP, Brazil

[2] Univ Sao Paulo, Inst Quim, Sao Carlos, SP, Brazil

来源：

LAB ON A CHIP | 2015年 / 15卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

COMPOSITE NANOPARTICLES;

D O I：

10.1039/c4lc01483a

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (phi = 10 nm) decorated with AuNPs (phi = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications.

引用

页码：1835 / 1841

页数：7

共 27 条

[11] A novel magnetic Fe3O4@gold composite nanomaterial: Synthesis and application in regeneration-free immunosensor [J].

Liang, Wenbin ;

Yi, Weijing ;

Li, Yan ;

Zhang, Zhujun ;

Yang, Mingzhen ;

Hu, Chuanmin ;

Chen, An .

MATERIALS LETTERS, 2010, 64 (23) :2616-2619

[12] Encapsulated Fe3O4/Ag Complexed Cores in Hollow Gold Nanoshells for Enhanced Theranostic Magnetic Resonance Imaging and Photothermal Therapy [J].

Lin, Adam Y. ;

Young, Joseph K. ;

Nixon, Ariel V. ;

Drezek, Rebekah A. .

SMALL, 2014, 10 (16) :3246-3251

[13] Synthesis of micro and nanostructures in microfluidic systems [J].

Marre, Samuel ;

Jensen, Klavs F. .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (03) :1183-1202

[14] Charged Gold Nanoparticles in Non-Polar Solvents: 10-min Synthesis and 2D Self-Assembly [J].

Martin, Matthew N. ;

Basham, James I. ;

Chando, Paul ;

Eah, Sang-Kee .

LANGMUIR, 2010, 26 (10) :7410-7417

[15] Higher surface energy of free nanoparticles [J].

Nanda, KK ;

Maisels, A ;

Kruis, FE ;

Fissan, H ;

Stappert, S .

PHYSICAL REVIEW LETTERS, 2003, 91 (10)

[16] Magnetically controlled single-nanoparticle detection via particle-electrode collisions [J].

Santos, Germano P. ;

Melo, Antonio F. A. A. ;

Crespilho, Frank N. .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2014, 16 (17) :8012-8018

[17] The Preparation of Magnetic Iron Oxide Nanoparticles in Microreactors [J].

Simmons, Matthew ;

Wiles, Charlotte ;

Rocher, Vincent ;

Francesconi, M. Grazia ;

Watts, Paul .

JOURNAL OF FLOW CHEMISTRY, 2013, 3 (01) :7-10

[18] Microfluidic synthesis of nanomaterials [J].

Song, Yujun ;

Hormes, Josef ;

Kumar, Challa S. S. R. .

SMALL, 2008, 4 (06) :698-711

[19] Surface enhanced Raman spectroscopic studies on magnetic Fe3O4@AuAg alloy core-shell nanoparticles [J].

Sun, Hai-Long ;

Xu, Min-Min ;

Guo, Qing-Hua ;

Yuan, Ya-Xian ;

Shen, Li-Ming ;

Gu, Ren-Ao ;

Yao, Jian-Lin .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2013, 114 :579-585

[20] THE EFFECT OF DROPLET SIZE ON SURFACE TENSION [J].

TOLMAN, RC .

JOURNAL OF CHEMICAL PHYSICS, 1949, 17 (03) :333-337

← 1 2 3 →