Automated production of 1-(2-[18F]fluoroethyl)-L-tryptophan for imaging of tryptophan metabolism

被引：6

作者：

Yue, Xuyi ^{[1
,2
]}

Xin, Yangchun ^{[1
,2
]}

Zhang, Shaohui ^{[1
,5
]}

Nikam, Rahul ^{[2
]}

Kandula, Vinay ^{[2
]}

Choudhary, Arabinda K. ^{[2
,6
]}

Chugani, Harry T. ^{[3
,7
]}

Chugani, Diane C. ^{[1
,4
,8
]}

机构：

[1] Nemours Alfred I duPont Hosp Children, Katzin Diagnost & Res PET MRI Ctr, 1600 Rockland Rd, Wilmington, DE 19803 USA

[2] Nemours Alfred I duPont Hosp Children, Dept Radiol, 1600 Rockland Rd, Wilmington, DE 19803 USA

[3] Nemours Alfred I duPont Hosp Children, Dept Neurol, 1600 Rockland Rd, Wilmington, DE 19803 USA

[4] Univ Delaware, Coll Hlth Sci, Commun Sci & Disorders, 100 Discovery Blvd, Newark, DE 19713 USA

[5] Progen Pharmaceut Inc, New York, NY 10007 USA

[6] Univ Arkansas Med Sci, Little Rock, AR 72205 USA

[7] NYU, Sch Med, New York, NY 10016 USA

[8] Univ Delaware, Newark, DE 19713 USA

来源：

APPLIED RADIATION AND ISOTOPES | 2020年 / 156卷 / 156期

关键词：

1-(2-[F-18]Fluoroethyl)-L-tryptophan; Tryptophan metabolism; Radiosynthesis; Current good manufacturing practice; METHYL-L-TRYPTOPHAN; POSITRON-EMISSION-TOMOGRAPHY; BRAIN-SEROTONIN SYNTHESIS; KYNURENINE PATHWAY; PET; CHILDREN; ACID; RADIOSYNTHESIS; KINETICS; TUBERS;

D O I：

10.1016/j.apradiso.2019.109022

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Automated production of an fluorine-18 labeled tryptophan analogue, 1-(2-[F-18]fluoroethyl)-L-tryptophan (1-L-[F-18]FETrp) in a current Good Manufacturing Practice facility was achieved. 1-L-[F-18]FETrp was produced by a one-pot, two-step strategy with an overall synthesis time of approximately 100 min, a radiochemical yield of 20 +/- 5% (decay corrected), radiochemical purity and enantiomeric excess over 90%, and a molar activity of 103 +/- 15 GBq/mu mol at the end of synthesis (EOS). The dose mass of 1-L-FETrp in four consecutive batches was less than 5 mu g. The radiopharmaceutical product met all quality control criteria for clinical use.

引用

页数：8

共 48 条

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