Investigation of surface plasmon biosensing using gold nanoparticles enhanced ellipsometry

被引：20
|
作者：
Moirangthem, Rakesh Singh [1 ,2 ,3 ]
Chang, Yia-Chung [1 ]
Wei, Pei-Kuen [1 ]
机构：
[1] Acad Sinica, Res Ctr Appl Sci, Taipei 115, Taiwan
[2] Acad Sinica, Nano Sci & Technol Program, TIGP, Taipei 115, Taiwan
[3] Natl Tsing Hua Univ, Dept Engn & Syst Sci, Hsinchu 300, Taiwan
来源：
OPTICS LETTERS | 2011年 / 36卷 / 05期
关键词：
RESONANCE; PHASE; GLASS;
D O I：
10.1364/OL.36.000775
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We present a label-free, nondestructive and high sensitivity biosensor by using the phase information of a gold nanoparticles enhanced ellipsometry signal. The refractive index (RI) resolution from ellipsometric phase information is of the order of 1.6 x 10(-6) RI units. Furthermore, spectroscopic and dynamic measurements show substantial change in the phase signal when biomolecules are coated on gold nanoparticles. The detection limit of our proposed technique is up to similar to 18pM concentration of the target biomolecules. (C) 2011 Optical Society of America
引用
收藏
页码：775 / 777
页数：3
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