Tributylhexadecylphosphonium bromide: an efficient reagent system for the one-pot synthesis of 2,4,5-trisubstituted imidazoles

被引：5

作者：

Heidari, Mohammad ^{[1
]}

Rezaei, Mohsen ^{[2
]}

Badri, Rashid ^{[1
]}

机构：

[1] Islamic Azad Univ, Coll Sci, Dept Chem, Ahvaz Branch, Ahvaz, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Ahvaz, Iran

来源：

HETEROCYCLIC COMMUNICATIONS | 2015年 / 21卷 / 02期

关键词：

2,4,5-trisubstituted imidazoles; aldehyde; benzil; homogeneous catalysis; one-pot synthesis; ALDEHYDES; 1,2-DIKETONES; CATALYST;

D O I：

10.1515/hc-2014-0182

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of benzil, an aromatic aldehyde, and ammonium acetate in ethanol at reflux in the presence of tributylhexadecylphosphonium bromide as catalyst affords a 2,4,5-trisubstituted imidazole. The present methodology offers several advantages over the literature methods, including excellent yields, shorter reaction times, environmentally benign milder reaction conditions, cost-effectiveness of catalyst, easy workup, and purification of products by nonchromatographic methods.

引用

页码：73 / 76

页数：4

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