Preparation of mono-labelled aliphatic polyacids via isoxazole derivatives

被引：8

作者：

Adamo, Mauro F. A. ^{[1
]}

Sarti-Fantoni, Piero ^{[2
]}

Chimichi, Stefano ^{[2
]}

Sandrelli, Alessandro ^{[2
]}

机构：

[1] Royal Coll Surgeons Ireland, CSCB, Dept Pharmaceut & Med Chem, Dublin 2, Ireland

[2] Univ Florence, Dipartimento Chim Organ U Schiff, I-50019 Sesto Fiorentino, Italy

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 48期

关键词：

Polyfunctional scaffolds; 4-Nitroisoxazole; O-18-bilabelled carboxylates; MULTICOMPONENT SYNTHESIS; ACIDS;

D O I：

10.1016/j.tetlet.2010.09.113

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method allowing the selective oxygen labelling of aliphatic polyacids, for example, succinic and glutaric acids, is reported. This process is based on the hydrolysis of a 3-alkyl-4-nitroisoxazol-5-yl group by (NaOH)-O-18 and affords the products in high yields. The same procedure was applied for the preparation of labelled aliphatic carboxylic acids. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6310 / 6312

页数：3

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