Serum free light chain analysis

被引：33

作者：

Davids, Matthew S. ^{[1
,2
]}

Murali, Mandakolathur R. ^{[2
,3
]}

Kuter, David J. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Hematol, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02114 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2010年 / 85卷 / 10期

关键词：

INDEPENDENT RISK-FACTOR; MONOCLONAL GAMMOPATHY; PROGRESSION; URINE; RATIO; IMMUNOFIXATION; AMYLOIDOSIS; REDUCTION; SURVIVAL; MARKERS;

D O I：

10.1002/ajh.21815

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a variety of hematologic malignancies, immunoglobulin light chains (LC) are overproduced clonally and circulate without being linked by disulphide bonds to the immunoglobulin heavy chain. The recent development of a robust assay known as kappa and gamma "free'' LC (FLC) to quantify the levels of these unbound LC in the serum, and thereby determine their ratio, has led to an explosion of studies that demonstrate its utility in a wide range of hematologic disorders. This article summarizes laboratory testing for serum FLC, with a particular focus on clinical applications for the test. Am. J. Hematol. 85:787-790, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：787 / 790

页数：4

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