Increased serum gamma-glutamyl-transpeptidase concentration is associated with nonalcoholic steatosis and not with cholestasis in patients with chronic hepatitis C

被引:15
作者
Benini, Federica
Pigozzi, Marie Graciella
Baisini, Ornella
Romanini, Laura
Ahmed, Hafez
Pozzi, Alessandro
Ricci, Chiara
Lanzini, Alberto
机构
[1] Spedali Civil Brescia, Dept Radiol, I-25125 Brescia, Italy
[2] Univ London St Georges Hosp, Sch Med, Div Gastroenterol Endocrinol & Metab, London, England
[3] Spedali Civil Brescia, SSD Gastroenterol, Dept Med, Gastroenterol Unit, I-25125 Brescia, Italy
[4] Univ Brescia, Brescia, Italy
关键词
gamma-glutamyl-transpeptidase; hepatitis C; serum bile acid; steatosis;
D O I
10.1111/j.1440-1746.2006.04733.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background and Aim: Increased pretreatment gamma-glutamyl-transpeptidase (gamma GT) is common in patients with chronic hepatitis C and with little or no alcohol consumption. The mechanism involved in this phenomenon is unclear, and the aim of this study was to investigate factors associated with increased gamma GT levels, specifically looking at the role of cholestasis that frequently accompanies hepatitis C. Methods: Fifty patients with chronic hepatitis C enrolled in two trials of antiviral treatment, 25 with normal and 25 with elevated pretreatment gamma GT levels, were retrospectively selected. In addition to the common liver function and virological tests, other values measured were serum bile acid concentration and composition by gas-chromatography as a sensitive index of cholestasis, and liver biopsy scores for cholestasis and steatosis in addition to siderosis, fibrosis and inflammation. Results: Total mean serum bile acid concentration was 11.6 +/- 1.4 mu mol/L and 8.5 +/- 1.2 mu mol/L (not significant) in patients with elevated and with normal gamma GT, respectively, and individual bile acid composition was similar in the two groups. By univariate analysis, serum gamma GT level was linearly related to total serum bile acid (P < 0.05) and to cholestasis score (P < 0.001) among other variables, but steatosis score (P < 0.001) and Knodell score (P < 0.04) were the only variables independently associated with elevated serum gamma GT level by multivariate analysis. Conclusions: Increased serum gamma GT level in patients with chronic hepatitis C is associated with liver steatosis and fibrosis, and indicates more advanced liver disease rather than reflecting the cholestasis that often accompanies this condition.
引用
收藏
页码:1621 / 1626
页数:6
相关论文
共 55 条
  • [41] γ-glutamyltransferase as a risk factor for cardiovascular disease mortality -: An epidemiological investigation in a cohort of 163,944 Austrian adults
    Ruttmann, E
    Brant, LJ
    Concin, H
    Diem, G
    Rapp, K
    Ulmer, H
    [J]. CIRCULATION, 2005, 112 (14) : 2130 - 2137
  • [42] FACTORS PREDICTIVE OF THE RESPONSE TO INTERFERON IN PATIENTS WITH CHRONIC HEPATITIS-C
    SERFATY, L
    GIRAL, P
    LORIA, A
    ANDREANI, T
    LEGENDRE, C
    POUPON, R
    [J]. JOURNAL OF HEPATOLOGY, 1994, 21 (01) : 12 - 17
  • [43] Serum total bile acid level as a sensitive indicator of hepatic histological improvement in chronic hepatitis C patients responding to interferon treatment
    Shima, T
    Tada, H
    Morimoto, M
    Nakagawa, Y
    Obata, H
    Sasaki, T
    Park, H
    Nakajo, S
    Nakashima, T
    Okanoue, T
    Kashima, K
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2000, 15 (03) : 294 - 299
  • [44] Hepatitis C virus infection and diabetes: Direct involvement of the virus in the development of insulin resistance
    Shintani, Y
    Fujie, H
    Miyoshi, H
    Tsutsumi, T
    Tsukamoto, K
    Kimura, S
    Moriya, K
    Koike, K
    [J]. GASTROENTEROLOGY, 2004, 126 (03) : 840 - 848
  • [45] Inflammation-induced cholestasis
    Trauner, M
    Fickert, P
    Stauber, RE
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1999, 14 (10) : 946 - 959
  • [46] SERUM BILE-ACIDS AND CHOLESTASIS IN ALCOHOLIC HEPATITIS - RELATIONSHIP WITH USUAL LIVER TESTS AND HISTOLOGICAL FEATURES
    TRINCHET, JC
    GERHARDT, MF
    BALKAU, B
    MUNZ, C
    POUPON, RE
    [J]. JOURNAL OF HEPATOLOGY, 1994, 21 (02) : 235 - 240
  • [47] Optimum dose of ursodeoxycholic acid in primary biliary cirrhosis
    Verma, A
    Jazrawi, RP
    Ahmed, HA
    Davis, T
    Bland, JM
    Benson, M
    Orchard, RT
    Theodossi, A
    Maxwell, JD
    Northfield, TC
    [J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1999, 11 (10) : 1069 - 1076
  • [48] VLAHCEVIC ZR, 1971, GASTROENTEROLOGY, V60, P491
  • [49] VLAHCEVIC ZR, 1972, GASTROENTEROLOGY, V62, P1174
  • [50] GAMMA-GLUTAMYL-TRANSFERASE - DETERMINANTS AND ASSOCIATION WITH MORTALITY FROM ISCHEMIC-HEART-DISEASE AND ALL CAUSES
    WANNAMETHEE, G
    EBRAHIM, S
    SHAPER, AG
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1995, 142 (07) : 699 - 708