Distribution of codon 129 genotype in human growth hormone-treated CJD patients in France and the UK

被引：73

作者：

Brandel, JP ^{[1
]}

Preece, M

Brown, P

Croes, E

Laplanche, JL

Agid, Y

Will, R

Alpérovitch, A

机构：

[1] Salpetriere Hosp, Natl Reference Ctr Latrogen CJD, F-75651 Paris 13, France

[2] Salpetriere Hosp, INSERM, U360, F-75651 Paris, France

[3] Inst Child Hlth, London, England

[4] NIH, Lab CNS Studies, Bethesda, MD 20892 USA

[5] Erasmus Univ, Sch Med, Rotterdam, Netherlands

[6] Lariboisiere Hosp, Cent Lab Biochem, Paris, France

[7] Western Gen Hosp, CJD Surveillance Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

LANCET | 2003年 / 362卷 / 9378期

关键词：

D O I：

10.1016/S0140-6736(03)13867-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since homozygosity MM at codon 129 of the prion protein gene is a recognised risk factor in all forms of Creutzfeldt-Jakob disease (CJD), we studied the distribution of codon 129 polymorphism in patients in France and in the UK with CJD transmitted iatrogenically by human growth hormone. The overall frequencies of codon 1.29 genotypes in these patients differed from those in the population unaffected by CJD. An excess of VV homozygotes was noted among those with iatrogenic CJD compared with sporadic CJD cases. The proportion of MM genotype in UK patients was surprisingly low (4%) compared with that in French patients (62%). There is no evident explanation for this different distribution, which might be due to infection with different strains of prion in human growth hormone.

引用

页码：128 / 130

页数：3

共 5 条

[1] Iatrogenic Creutzfeldt-Jakob disease at the millennium
Brown, P
Preece, M
Brandel, JP
Sato, T
McShane, L
Zerr, I
Fletcher, A
Will, RG
Pocchiari, M
Cashman, NR
d'Aignaux, JH
Cervenáková, L
Fradkin, J
Schonberger, LB
Collins, SJ
[J]. NEUROLOGY, 2000, 55 (08) : 1075 - 1081
[2] PRP GENOTYPE AND AGENT EFFECTS IN SCRAPIE - CHANGE IN ALLELIC INTERACTION WITH DIFFERENT ISOLATES OF AGENT IN SHEEP, A NATURAL HOST OF SCRAPIE
GOLDMANN, W
HUNTER, N
SMITH, G
FOSTER, J
HOPE, J
[J]. JOURNAL OF GENERAL VIROLOGY, 1994, 75 : 989 - 995
[3] MOLECULAR-GENETICS OF PRION DISEASES IN FRANCE
LAPLANCHE, JL
DELASNERIELAUPRETRE, N
BRANDEL, JP
CHATELAIN, J
BEAUDRY, P
ALPEROVITCH, A
LAUNAY, JM
[J]. NEUROLOGY, 1994, 44 (12) : 2347 - 2351
[4] HOMOZYGOUS PRION PROTEIN GENOTYPE PREDISPOSES TO SPORADIC CREUTZFELDT-JAKOB DISEASE
PALMER, MS
DRYDEN, AJ
HUGHES, JT
COLLINGE, J
[J]. NATURE, 1991, 352 (6333) : 340 - 342
[5] Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959-85: a cohort study
Swerdlow, AJ
Higgins, CD
Adlard, P
Preece, MA
[J]. LANCET, 2002, 360 (9329) : 273 - 277

← 1 →