Implications of peritoneal cancer index distribution on patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

被引：5

作者：

Wong, Jolene Si Min ^{[1
,2
,3
,4
]}

Tan, Grace Hwei Ching ^{[1
,2
]}

Cheok, Sabrina Hui Xian ^{[1
,2
]}

Ong, Chin-Ann Johnny ^{[1
,2
,3
,4
,5
,6
]}

Chia, Claramae Shulyn ^{[1
,2
,3
,4
]}

Teo, Melissa Ching Ching ^{[1
,2
,3
,4
]}

机构：

[1] Natl Canc Ctr Singapore, Dept Sarcoma Peritoneal & Rare Tumours SPRinT, Div Surg & Surg Oncol, 11 Hosp Crescent, Singapore 169610, Singapore

[2] Singapore Gen Hosp, Dept Sarcoma Peritoneal & Rare Tumours SPRinT, Div Surg & Surg Oncol, Singapore, Singapore

[3] Duke NUS Med Sch, SingHlth Duke NUS Surg Acad Med Program, Singapore, Singapore

[4] Duke NUS Med Sch, SingHlth Duke NUS Oncol Acad Med Program, Singapore, Singapore

[5] Natl Canc Ctr Singapore, Div Med Sci, Lab Appl Human Genet, Singapore, Singapore

[6] A STAR Res Ent, Inst Mol & Cell Biol, Singapore, Singapore

来源：

PLEURA AND PERITONEUM | 2022年 / 7卷 / 02期

基金：

英国医学研究理事会;

关键词：

cytoreductive surgery; hyperthermic intraperitoneal chemotherapy; peritoneal cancer index; MANAGEMENT; HIPEC;

D O I：

10.1515/pp-2021-0150

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: Peritoneal cancer index (PCI) score is a common prognostication tool in peritoneal metastases (PM). We hypothesize that the distribution of PCI score and involvement of specific regions affects survival and morbidity outcomes. Methods: Data was collected from a prospective database of patients who underwent CRS and HIPEC for PM at the National Cancer Centre Singapore. We evaluate the relationship between PCI, PCI distribution, and survival and morbidity outcomes. Results: One hundred and fifty-two patients underwent CRS and HIPEC with a median PCI score of nine (range 0-31). Median overall survival (OS) and progression free survival (PFS) were 43 and 17 months, respectively. Region six (pelvis) was most commonly involved and had the highest frequency of heavy disease burden. Presence of PM in the lower abdomen, flanks, and small bowel were associated with poorer OS (p=0.01, 0.03, <0.001) and PFS (p=0.04, 0.02, <0.001). Involvement of porta hepatitis predicted poorer OS but not PFS (p=0.03). Involvement of the gastric antrum resulted in higher rates of postoperative complications. Conclusions: The pattern of PCI distribution may be associated with varying survival and morbidity outcomes.

引用

页码：95 / 102

页数：8

共 29 条

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