Percutaneous left atrial appendage closure followed by single antiplatelet therapy: Short- and mid-term outcomes

Background. - After left atrial appendage closure (LAAC), various antithrombotic protocols have been suggested, but the optimal post-procedural antithrombotic strategy is still under debate. Aims. - To investigate the efficacy and safety of LAAC with an AMPLATZER (TM) Cardiac Plug (ACP) device (St. Jude Medical, Minneapolis, MN, USA) followed by single antiplatelet therapy. Methods. - Consecutive patients with non-valvular atrial fibrillation and a contraindication for oral anticoagulants who underwent LAAC with an ACP device between 2012 and 2014 in two French centres were included. Follow-up included clinical evaluation at 1, 3, 6 and 12 months, and yearly thereafter, and a cardiac computed tomography scan at 3 months to assess device position, device-related thrombus and residual leak. Single antiplatelet therapy was prescribed after the procedure for at least 12 months. Results. - A total of 76 patients underwent successful LAAC (mean age: 73 years; 59% men; mean CHA(2)DS(2)-VASc score 4.4 +/- 1.3; mean HAS-BLED score 3.4 +/- 0.9). Three major complications occurred during the periprocedural period (one cardiac tamponade and two access site haematomas). Device thrombosis was observed at 3 months in five (6.8%) patients who remained asymptomatic. After a mean follow-up of 13 months, the rates of death, stroke and major bleeding were 2.6%, 4.0% and 1.3%, respectively. Embolic and bleeding events were less frequent than expected from CHA(2)DS(2)-VASc (4.0% vs 9.9%; P < 0.001) and HAS-BLED (1.3% vs 4.3%; P < 0.001) risk scores. Conclusions. - LAAC using an ACP device followed by single antiplatelet therapy could be a reasonable alternative for stroke prevention. (C) 2016 Elsevier Masson SAS. All rights reserved.