Palladium-catalyzed regioselective C-H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles

被引：43

作者：

Fang, Songjia ^{[2
]}

Jiang, Guangbin ^{[2
]}

Li, Meng ^{[2
]}

Liu, Zhenying ^{[2
]}

Jiang, Huanfeng ^{[2
]}

Wu, Wanqing ^{[1
,2
]}

机构：

[1] South China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Guangdong, Peoples R China

[2] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 91期

基金：

中国国家自然科学基金;

关键词：

BOND ALKYNYLATION; BROMOALKYNES; ARYLATION; POWERFUL; PYRROLES; ALKYNES; ARENES; ACIDS;

D O I：

10.1039/c9cc07263b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed uniquely regioselective C-H alkynylation of indoles has been described. In this protocol, simple and readily available haloalkynes are employed as efficient alkynylating reagents, affording a series of functionalized 7-alkynylindoles in moderate to good yields. Moreover, further transformations of 7-alkynylated products were performed, which demonstrated the potential application of this method in organic synthesis.

引用

页码：13769 / 13772

页数：4

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