Serum paraoxonase activity and its relationship to diabetic complications in patients with non-insulin-dependent diabetes mellitus

被引：130

作者：

Ikeda, Y ^{[1
]}

Suehiro, T ^{[1
]}

Inoue, M ^{[1
]}

Nakauchi, Y ^{[1
]}

Morita, T ^{[1
]}

Arii, K ^{[1
]}

Ito, H ^{[1
]}

Kumon, Y ^{[1
]}

Hashimoto, K ^{[1
]}

机构：

[1] Kochi Med Sch, Dept Internal Med 2, Nanko Ku, Kohasu, Kochi 783, Japan

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1998年 / 47卷 / 05期

关键词：

D O I：

10.1016/S0026-0495(98)90246-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Paraoxonase (PON) is an esterase associated with high-density lipoprotein (HDL). Serum PON activity is affected by PON gene polymorphism (L/M, Leu-Met54, and Q/R,Gln-Arg191). We investigated PON activity and polymorphism in 108 patients (53 men and 55 women) with non-insulin-dependent diabetes mellitus (NIDDM) and 161 control subjects (82 men and 79 women) matched to the patients by age and gender. Serum PON activity was determined using paraoxon as a substrate. PON gene polymorphisms were detected by the restriction fragment length polymorphism method after a polymerase chain reaction. The mean PON activity in the patients was significantly lower than in the controls (116 +/- 55 and 162 +/- 57 U/L, respectively, P <.001). The distribution of each genotype showed no difference between the patient and control groups, and PON activity increased in the order of the QQ < OR < RR genotype and MM < LM < LL genotype in both groups. However, among each genotype subgroup, the activity was lower in patients than in controls. Forty-one patients with retinopathy had lower PON activity than those without the complication (94 +/- 36 and 129 +/- 61 U/L, respectively, P <.002). There was also a significant difference in PON activity between patients with and without overt proteinuria (93 +/- 38 and 122 +/- 58 U/L, respectively, P <.05). Logistic analysis showed that serum PON activity was one of the significant factors for retinopathy. These results suggest that decreased PON activity in patients with NIDDM is involved in diabetic vascular complications. Copyright (C) 1998 by W.B. Saunders Company.

引用

页码：598 / 602

页数：5

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