Fluorine-containing 1,4-dihydropyridines

被引：4
作者：
Yagupolskii, LM
Maletina, II
Petko, KI
Fedyuk, DV
机构：
[1] Institute of Organic Chemistry, Natl. Acad. of Sciences of Ukraine, 253660 Kiev-94
来源：
JOURNAL OF FLUORINE CHEMISTRY | 1996年 / 80卷 / 01期
关键词：
1,4-dihydropyridines; fluorine-containing substituents; cardiovascular drugs; calcium channels; potassium channels;
D O I：
10.1016/S0022-1139(96)03450-1
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of 1,4-dihydropyridines with fluorine-containing substituents of various electronic nature and lipophilicity, as synthesized in our Department, are considered and their biological activity as calcium channels modulators is discussed. A 'hybrid' compound-a combination of calcium channels blocker and potassium channels activator-has also been synthesized.
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页码：3 / 7
页数：5
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