Electrochemical oxidation synergizing with BrOnsted-acid catalysis leads to [4+2] annulation for the synthesis of pyrazines

被引：34
|
作者：
Liu, Kun [1 ]
Song, Chunlan [1 ]
Wu, Jiarong [1 ]
Deng, Yuqi [1 ]
Tang, Shan [1 ]
Lei, Aiwen [1 ,2 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, IAS, Wuhan 430072, Hubei, Peoples R China
[2] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China
来源：
GREEN CHEMISTRY | 2019年 / 21卷 / 04期
基金：
中国国家自然科学基金;
关键词：
ONE-POT SYNTHESIS; H ACTIVATION; ELECTROSYNTHESIS; QUINOXALINES; AMINATION; OXYGENATION; INHIBITORS; EMISSION; ALCOHOLS; N-BU4NI;
D O I：
10.1039/c8gc03786h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An electrochemical dehydrogenative [4 + 2] annulation for the synthesis of pyrazines has been developed under undivided electrolytic conditions. In this protocol, neither external chemical oxidants nor transition-metal catalysts are needed, and a wide range of substituted pyrazines could be obtained from simple ketones and diamines in high efficiencies. Of note is that this electrolysis could also be extended for the construction of biheteroarenes and large systems with good yields.
引用
收藏
页码：765 / 769
页数：5
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