B-Type Natriuretic Peptide: From Posttranslational Processing to Clinical Measurement

被引:30
作者
Goetze, Jens P. [1 ]
机构
[1] Univ Copenhagen, Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark
关键词
CONGESTIVE-HEART-FAILURE; HUMAN BLOOD EVALUATION; NT-PROBNP; VENTRICULAR EXPRESSION; POTENTIAL BIOMARKER; CARDIAC-HYPERTROPHY; SERINE-PROTEASE; GENE-EXPRESSION; ENDOCRINE HEART; HUMAN PLASMA;
D O I
10.1373/clinchem.2011.165696
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
BACKGROUND: Plasma cardiac natriuretic peptides and peptide fragments from their molecular precursors are markers of heart disease. Clinical studies have defined the current diagnostic utility of these markers, whereas biochemical elucidation of peptide structure and post-translational processing has revealed new plasma peptide forms of potential clinical use. CONTENT: Natriuretic propeptide structures undergo variable degrees of endo-and exoproteolytic cleavages as well as amino acid modifications, which leave the plasma phase of the peptides highly heterogeneous and dependent on cardiac pathophysiology and capacity. An ongoing characterization of the molecular heterogeneity may not only help us to appreciate the biosynthetic capacity of the endocrine heart but may also lead to the discovery of new and more disease-specific targets for future molecular diagnosis. SUMMARY: Peptides derived from pro-atrial natriuretic peptide and pro-B-type natriuretic peptide are useful plasma markers in heart failure. New data have defined cardiac myocytes as competent endocrine cells in post-translational processing and cellular secretion. (C) 2011 American Association for Clinical Chemistry
引用
收藏
页码:83 / 91
页数:9
相关论文
共 97 条
[1]   DPP-4 inhibitors [J].
Ahren, Bo .
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 21 (04) :517-533
[2]  
Asano K, 1999, AM J VET RES, V60, P860
[3]   Activation of endoplasmic reticulum stress response during the development of ischemic heart disease [J].
Azfer, Asim ;
Niu, Jianli ;
Rogers, Linda M. ;
Adamski, Frances M. ;
Kolattukudy, Pappachan E. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 291 (03) :H1411-H1420
[4]   Acid prohormone sequence determines size, shape, and docking of secretory vesicles in atrial myocytes [J].
Baertschi, AJ ;
Monnier, D ;
Schmidt, U ;
Levitan, ES ;
Fakan, S ;
Roatti, A .
CIRCULATION RESEARCH, 2001, 89 (03) :E23-E29
[5]  
BEAUBIEN G, 1995, CELL TISSUE RES, V279, P539
[6]   PROHORMONE-CONVERTING ENZYMES - REGULATION AND EVALUATION OF FUNCTION USING ANTISENSE RNA [J].
BLOOMQUIST, BT ;
EIPPER, BA ;
MAINS, RE .
MOLECULAR ENDOCRINOLOGY, 1991, 5 (12) :2014-2024
[7]   Dilpeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form [J].
Brandt, I ;
Lambeir, AM ;
Ketelslegers, JM ;
Vanderheyden, M ;
Scharpé, S ;
De Meester, I .
CLINICAL CHEMISTRY, 2006, 52 (01) :82-87
[8]   CONCENTRATIONS OF N-TERMINAL PROANP IN HUMAN PLASMA - EVIDENCE FOR PROANP (1-98) AS THE CIRCULATING FORM [J].
BUCKLEY, MG ;
SAGNELLA, GA ;
MARKANDU, ND ;
SINGER, DRJ ;
MACGREGOR, GA .
CLINICA CHIMICA ACTA, 1990, 191 (1-2) :1-14
[9]   ATRIAL-NATRIURETIC-PEPTIDE ELEVATION IN CONGESTIVE-HEART-FAILURE IN THE HUMAN [J].
BURNETT, JC ;
KAO, PC ;
HU, DC ;
HESER, DW ;
HEUBLEIN, D ;
GRANGER, JP ;
OPGENORTH, TJ ;
REEDER, GS .
SCIENCE, 1986, 231 (4742) :1145-1147
[10]   Secretory granule targeting of atrial natriuretic peptide correlates with its calcium-mediated aggregation [J].
Canaff, L ;
Brechler, V ;
Reudelhuber, TL ;
Thibault, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9483-9487