Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation

被引：6

作者：

Bao, Qi ^{[1
,2
,3
,5
]}

Li, Chong ^{[4
]}

Xu, Chongfeng ^{[3
]}

Zhang, Ruiying ^{[3
]}

Zhao, Kai ^{[1
,2
]}

Duan, Ziyuan ^{[3
]}

机构：

[1] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Qinghai, Peoples R China

[2] Chinese Acad Sci, Northwest Inst Plateau Biol, Lab Plateau Fish Evolutionary & Funct Genom, Xining 810001, Qinghai, Peoples R China

[3] Chinese Acad Sci, Genet Resource Ctr, Inst Genet & Dev Biol, Beijing 100101, Peoples R China

[4] Chinese Acad Sci, Inst Biophys, Core Facil Prot Res, Beijing 100101, Peoples R China

[5] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

GENE | 2018年 / 646卷

关键词：

Btnl5; IECs; NF-kappa B; Immune regulation; Interacting proteins; ULCERATIVE-COLITIS; GENE FAMILY; INFLAMMATION; ALPHA; BUTYROPHILINS; HOMEOSTASIS; ACTIVATION; CELLS;

D O I：

10.1016/j.gene.2017.11.070

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Porcine butyrophilin-like 5 (Btnl5) is a novel member of the butyrophilin family, which consists of immune regulators. The expression pattern and the function of this gene remain unclear. In this study, Btnl5 is identified as a negative regulator of the NF-kappa B pathway. Our study indicates that Btnl5 is mainly expressed in intestinal epithelial cells (IECs) and expressed in membrane systems. Btnl5 inhibits MyD88-mediated activation of the NF-kappa B pathway. Btnl5 interacts with TNF receptor-associated factor 2 (TRAF2) and transcription factor p65. Besides, Btnl5 inhibits p65-mediated activation of the NF-kappa B pathway and inhibits nuclear translocation of p65. These results suggest that Btnl5 may inhibit NF-kappa B pathway through binding and interfere nuclear translocation of p65.

引用

页码：47 / 55

页数：9

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