Regioselective Synthesis of Trialkylpyrazines via Nickel-Catalyzed Negishi Cross-Coupling of Pyrazine Triflate

被引：7

作者：

Pitchaiah, Arigala ^{[1
]}

Hwang, In Taek ^{[1
]}

Hwang, Jin-Soo ^{[1
]}

Kim, Hyungrok ^{[1
]}

Lee, Kee-In ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Green Chem Div, Taejon 305600, South Korea

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 11期

关键词：

trialkylpyrazine; pheromone; Negishi cross-coupling; pyrazine triflate; organozinc halide; TETRASUBSTITUTED PYRAZINES; SUBSTITUTED PYRAZINES; GRIGNARD-REAGENTS; N-OXIDES; PHEROMONE; IDENTIFICATION; ALKYLPYRAZINES; COMPLEXES; VOLATILES; ALKYNES;

D O I：

10.1055/s-0031-1290972

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A regioselective synthesis of trialkylpyrazines via nickel-catalyzed cross-coupling reaction of pyrazine triflate is reported. The 5-substituted 2,3-dimethylpyrazine derivatives including trail pheromone components of the ant Eutetramorium mocquerysi have been successfully synthesized in good yields by nickel-catalyzed Negishi cross-coupling reactions of pyrazine triflate mediated by alkyl and arylzinc halides.

引用

页码：1631 / 1636

页数：6

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