Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders

被引：240
作者：
Lehr, Stefan [1 ]
Hartwig, Sonja [1 ]
Sell, Henrike [2 ]
机构：
[1] German Diabet Ctr, Inst Clin Biochem & Pathobiochem, Dusseldorf, Germany
[2] German Diabet Ctr, Paul Langerhans Grp, Dusseldorf, Germany
来源：
PROTEOMICS CLINICAL APPLICATIONS | 2012年 / 6卷 / 1-2期
关键词：
Adipokines; Adipose tissue; Organ crosstalk; Proteomic profiling; Secretome; VISCERAL ADIPOSE-TISSUE; NECROSIS-FACTOR-ALPHA; DESORPTION/IONIZATION MASS-SPECTROMETRY; MONOCYTE CHEMOATTRACTANT PROTEIN-1; DIFFERENCE GEL-ELECTROPHORESIS; INSULIN-SENSITIVE OBESITY; LOW-ABUNDANCE PROTEINS; CELL-CULTURE SILAC; PROTEOMIC ANALYSIS; AMINO-ACIDS;
D O I：
10.1002/prca.201100052
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins, termed adipokines, via which adipose tissue communicates with other organs. Expansion of adipose tissue in obesity alters adipokine secretion which may contribute to the development of metabolic diseases. Consequently, this correlation has emphasized the importance to further characterize the adipocyte secretion profile, and several attempts have been made to characterize the complex nature of the adipose tissue secretome by utilizing diverse proteomic profiling approaches. Although the entirety of human adipokines is still incompletely characterized, to date more than 600 potentially secretory proteins were identified providing a rich source to identify putative novel biomarkers associated with metabolic diseases.
引用
收藏
页码：91 / 101
页数：11
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