Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders

被引：240
作者：
Lehr, Stefan [1 ]
Hartwig, Sonja [1 ]
Sell, Henrike [2 ]
机构：
[1] German Diabet Ctr, Inst Clin Biochem & Pathobiochem, Dusseldorf, Germany
[2] German Diabet Ctr, Paul Langerhans Grp, Dusseldorf, Germany
来源：
PROTEOMICS CLINICAL APPLICATIONS | 2012年 / 6卷 / 1-2期
关键词：
Adipokines; Adipose tissue; Organ crosstalk; Proteomic profiling; Secretome; VISCERAL ADIPOSE-TISSUE; NECROSIS-FACTOR-ALPHA; DESORPTION/IONIZATION MASS-SPECTROMETRY; MONOCYTE CHEMOATTRACTANT PROTEIN-1; DIFFERENCE GEL-ELECTROPHORESIS; INSULIN-SENSITIVE OBESITY; LOW-ABUNDANCE PROTEINS; CELL-CULTURE SILAC; PROTEOMIC ANALYSIS; AMINO-ACIDS;
D O I：
10.1002/prca.201100052
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins, termed adipokines, via which adipose tissue communicates with other organs. Expansion of adipose tissue in obesity alters adipokine secretion which may contribute to the development of metabolic diseases. Consequently, this correlation has emphasized the importance to further characterize the adipocyte secretion profile, and several attempts have been made to characterize the complex nature of the adipose tissue secretome by utilizing diverse proteomic profiling approaches. Although the entirety of human adipokines is still incompletely characterized, to date more than 600 potentially secretory proteins were identified providing a rich source to identify putative novel biomarkers associated with metabolic diseases.
引用
收藏
页码：91 / 101
页数：11
相关论文
共 131 条
  • [1] Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    Alberti, K. G. M. M.
    Eckel, Robert H.
    Grundy, Scott M.
    Zimmet, Paul Z.
    Cleeman, James I.
    Donato, Karen A.
    Fruchart, Jean-Charles
    James, W. Philip T.
    Loria, Catherine M.
    Smith, Sidney C., Jr.
    [J]. CIRCULATION, 2009, 120 (16) : 1640 - 1645
  • [2] Characterization of the human visceral adipose tissue secretome
    Alvarez-Llamas, Gloria
    Szalowska, Ewa
    de Vries, Marcel P.
    Weening, Desiree
    Landman, Karloes
    Hoek, Annemieke
    Wolffenbuttel, Bruce H. R.
    Roelofsen, Han
    Vonk, Roel J.
    [J]. MOLECULAR & CELLULAR PROTEOMICS, 2007, 6 (04) : 589 - 600
  • [3] Importance of weight management in Type 2 diabetes: Review with meta-analysis of clinical studies
    Anderson, JW
    Kendall, CWC
    Jenkins, DJA
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2003, 22 (05) : 331 - 339
  • [4] Central regulation of energy balance: inputs, outputs and leptin resistance
    Arch, JRS
    [J]. PROCEEDINGS OF THE NUTRITION SOCIETY, 2005, 64 (01) : 39 - 46
  • [5] Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
    Arita, Y
    Kihara, S
    Ouchi, N
    Maeda, K
    Kuriyama, H
    Okamoto, Y
    Kumada, M
    Hotta, K
    Nishida, M
    Takahashi, M
    Nakamura, T
    Shimomura, I
    Muraguchi, M
    Ohmoto, Y
    Funahashi, T
    Matsuzawa, Y
    [J]. CIRCULATION, 2002, 105 (24) : 2893 - 2898
  • [6] Asirvatham VS, 2002, PROTEOMICS, V2, P960, DOI 10.1002/1615-9861(200208)2:8<960::AID-PROT960>3.0.CO
  • [7] 2-2
  • [8] Feature-based prediction of non-classical and leaderless protein secretion
    Bendtsen, JD
    Jensen, LJ
    Blom, N
    von Heijne, G
    Brunak, S
    [J]. PROTEIN ENGINEERING DESIGN & SELECTION, 2004, 17 (04) : 349 - 356
  • [9] Comparison of different depletion strategies for improved resolution in proteomic analysis of human serum samples
    Björhall, K
    Miliotis, T
    Davidsson, P
    [J]. PROTEOMICS, 2005, 5 (01) : 307 - 317
  • [10] The distinction of metabolically 'healthy' from 'unhealthy' obese individuals
    Blueher, Matthias
    [J]. CURRENT OPINION IN LIPIDOLOGY, 2010, 21 (01) : 38 - 43
12345678910