Coupling reactions of cephalosporin sulfones: A stable 3-stannylated cephem

被引：21

作者：

Buynak, JD ^{[1
]}

Vogeti, L ^{[1
]}

Chen, HS ^{[1
]}

机构：

[1] So Methodist Univ, Dept Chem, Dallas, TX 75275 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 19期

关键词：

D O I：

10.1021/ol016142v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The first stable 3-metalated cephalosporin is reported and shown to be an excellent synthetic precursor to a number of prospective beta -lactamase inhibitors.

引用

页码：2953 / 2956

页数：4

共 19 条

[1] ORGANOTIN COMPOUNDS .33. THE 1ST COMPLEX-FORMATION BETWEEN ORGANOTIN AND NITRO-DERIVATIVES - REACTIONS OF THE TIN-ALKYL BOND [J].

ALALLAF, TAK ;

KOBS, U ;

NEUMANN, WP .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1989, 373 (01) :29-35

[2]

Bush K, 1998, ADV EXP MED BIOL, V456, P71

[3]

Buynak JD, 2000, BIOORG MED CHEM LETT, V10, P853, DOI 10.1016/S0960-894X(00)00098-6

[4] A convenient method for the production of 6-oxopenicillinates and 7-oxocephalosporinates [J].

Buynak, JD ;

Rao, AS ;

Nidamarthy, SD .

TETRAHEDRON LETTERS, 1998, 39 (28) :4945-4946

[5] The synthesis and evaluation of 6-alkylidene-2′β-substituted penam sulfones as β-lactamase inhibitors [J].

Buynak, JD ;

Rao, AS ;

Doppalapudi, VR ;

Adam, G ;

Petersen, PJ ;

Nidamarthy, SD .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (14) :1997-2002

[6] The synthesis and evaluation of 2-substituted-7(alkylidene)cephalosporin sulfones as β-lactamase inhibitors [J].

Buynak, JD ;

Doppalapudi, VR ;

Rao, AS ;

Nidamarthy, SD ;

Adam, G .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (09) :847-851

[7] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 7-ALKYLIDENECEPHEMS [J].

BUYNAK, JD ;

WU, KC ;

BACHMANN, B ;

KHASNIS, D ;

HUA, L ;

NGUYEN, HK ;

CARVER, CL .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (06) :1022-1034

[8] Inhibition of class C β-lactamases:: Structure of a reaction intermediate with a cephem sulfone [J].

Crichlow, GV ;

Nukaga, M ;

Doppalapudi, VR ;

Buynak, JD ;

Knox, JR .

BIOCHEMISTRY, 2001, 40 (21) :6233-6239

[9] A GENERAL-ROUTE TO 3-FUNCTIONALIZED 3-NORCEPHALOSPORINS [J].

FARINA, V ;

BAKER, SR ;

HAUCK, SI .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (20) :4962-4966

[10] PALLADIUM CATALYSIS IN CEPHALOSPORIN CHEMISTRY - A VERSATILE NEW APPROACH TO 3-SUBSTITUTED CEPHEMS [J].

FARINA, V ;

BAKER, SR ;

SAPINO, C .

TETRAHEDRON LETTERS, 1988, 29 (47) :6043-6046

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