Microwave-assisted solid-phase Dotz benzannulation reaction: a facile synthesis of 2,3-disubstituted-1,4-naphthoquinones

被引：14

作者：

Shanmugasundaram, M ^{[1
]}

Garcia-Martinez, I ^{[1
]}

Li, QY ^{[1
]}

Estrada, A ^{[1
]}

Martinez, NE ^{[1
]}

Martinez, LE ^{[1
]}

机构：

[1] Univ Texas, Dept Chem, El Paso, TX 79968 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 44期

基金：

美国国家卫生研究院;

关键词：

solid-phase synthesis; microwave; Dotz reaction; 1,4-naphthoquinones; Fischer carbenes;

D O I：

10.1016/j.tetlet.2005.08.158

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A microwave-assisted solid-supported Dotz benzannulation of chromium carbene complexes with various alkynes has been developed. The oxidative cleavage of the resulting resin-bound 1,4-naphthols affords 2,3-disubstituted-1,4-naphthoquinone derivatives in good to moderate yields with high purities. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：7545 / 7548

页数：4

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