Barriers to using clozapine in treatment-resistant schizophrenia: systematic review

被引：129
作者：
Farooq, Saeed [1 ]
Choudry, Abid [2 ]
Cohen, Dan [3 ]
Naeem, Farooq [4 ]
Ayub, Muhammad [5 ]
机构：
[1] Keele Univ, Res Inst Primary Care & Hlth Sci, Keele, Staffs, England
[2] Birmingham Womens & Childrens NHS Fdn Trust, Forward Thinking Birmingham, Birmingham, W Midlands, England
[3] Mental Hlth Org North Holland North Heerhugowaard, Dept Community Mental Hlth, Heerhugowaard, Netherlands
[4] Queens Univ, Kingston, ON, Canada
[5] Queens Univ, Dept Psychiat, Div Dev Disabil, Kingston, ON, Canada
来源：
BJPSYCH BULLETIN | 2019年 / 43卷 / 01期
关键词：
Treatment resistant schizophrenia; clozapine; barriers;
D O I：
10.1192/bjb.2018.67
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Aims and method To systematically review the literature on barriers to the use of clozapine and identify any interventions for optimizing clozapine use in treatment-resistant schizophrenia. Journal databases were searched from 1972 to March 2018. The following search terms were used: treatment-resistant schizophrenia, clozapine, barriers, use, prescription rates, implementation, clozaril and prescribing practices. Following a review of the literature, 15 papers were included in the review. Results The major barriers that were identified included mandatory blood testing, fear of serious side-effects and lack of adherence by the patients, difficulty in identifying suitable patients, service fragmentation, and inadequate training in or exposure to using clozapine.
引用
收藏
页码：8 / 16
页数：9
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