Barriers to using clozapine in treatment-resistant schizophrenia: systematic review

被引：129

作者：

Farooq, Saeed ^{[1
]}

Choudry, Abid ^{[2
]}

Cohen, Dan ^{[3
]}

Naeem, Farooq ^{[4
]}

Ayub, Muhammad ^{[5
]}

机构：

[1] Keele Univ, Res Inst Primary Care & Hlth Sci, Keele, Staffs, England

[2] Birmingham Womens & Childrens NHS Fdn Trust, Forward Thinking Birmingham, Birmingham, W Midlands, England

[3] Mental Hlth Org North Holland North Heerhugowaard, Dept Community Mental Hlth, Heerhugowaard, Netherlands

[4] Queens Univ, Kingston, ON, Canada

[5] Queens Univ, Dept Psychiat, Div Dev Disabil, Kingston, ON, Canada

来源：

BJPSYCH BULLETIN | 2019年 / 43卷 / 01期

关键词：

Treatment resistant schizophrenia; clozapine; barriers;

D O I：

10.1192/bjb.2018.67

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Aims and method To systematically review the literature on barriers to the use of clozapine and identify any interventions for optimizing clozapine use in treatment-resistant schizophrenia. Journal databases were searched from 1972 to March 2018. The following search terms were used: treatment-resistant schizophrenia, clozapine, barriers, use, prescription rates, implementation, clozaril and prescribing practices. Following a review of the literature, 15 papers were included in the review. Results The major barriers that were identified included mandatory blood testing, fear of serious side-effects and lack of adherence by the patients, difficulty in identifying suitable patients, service fragmentation, and inadequate training in or exposure to using clozapine.

引用

页码：8 / 16

页数：9

共 33 条

[1]

[Anonymous], 2016, CLOZAPINE UNDERUTILI

[2]

[Anonymous], PROSPERO

[3]

[Anonymous], PSYCH SCHIZ AD

[4] Survey on schizophrenia treatment in Mexico: perception and antipsychotic prescription patterns [J].