A role of thrombin receptor signaling in endothelial cells during embryonic development

被引：227

作者：

Griffin, CT ^{[1
]}

Srinivasan, Y ^{[1
]}

Zheng, YW ^{[1
]}

Huang, W ^{[1
]}

Coughlin, SR ^{[1
]}

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

来源：

SCIENCE | 2001年 / 293卷 / 5535期

关键词：

D O I：

10.1126/science.1061259

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The coagulation protease thrombin triggers fibrin formation, platelet activation, and other cellular responses at sites of tissue injury. We report a rote for PAR1, a protease-activated G protein-coupled receptor for thrombin, in em,. bryonic development. Approximately half of Par1(-/-) mouse embryos died at midgestation with bleeding from multiple sites. PAR1 is expressed in endothelial cells, and a PAR1 transgene driven by an endothetial-specific promoter prevented death of Par1(-/-) embryos. our results suggest that the coagulation cascade and PAR1 modulate endothelial cell function in developing blood vessels and that thrombin's actions on endothelial cells-rather than on platelets, mesenchymal cells, or fibrinogen-contribute to vascular development and hemostasis in the mouse embryo.

引用

页码：1666 / 1670

页数：5

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