A role of thrombin receptor signaling in endothelial cells during embryonic development

被引：225
作者：
Griffin, CT [1 ]
Srinivasan, Y [1 ]
Zheng, YW [1 ]
Huang, W [1 ]
Coughlin, SR [1 ]
机构：
[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
来源：
SCIENCE | 2001年 / 293卷 / 5535期
关键词：
D O I：
10.1126/science.1061259
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The coagulation protease thrombin triggers fibrin formation, platelet activation, and other cellular responses at sites of tissue injury. We report a rote for PAR1, a protease-activated G protein-coupled receptor for thrombin, in em,. bryonic development. Approximately half of Par1(-/-) mouse embryos died at midgestation with bleeding from multiple sites. PAR1 is expressed in endothelial cells, and a PAR1 transgene driven by an endothetial-specific promoter prevented death of Par1(-/-) embryos. our results suggest that the coagulation cascade and PAR1 modulate endothelial cell function in developing blood vessels and that thrombin's actions on endothelial cells-rather than on platelets, mesenchymal cells, or fibrinogen-contribute to vascular development and hemostasis in the mouse embryo.
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收藏
页码：1666 / 1670
页数：5
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